M. Bastaki, V. Lu, Michel Aubanel, H. Bialk, Christopher Choi, J. Demyttenaere, Maodo Malick Diop, Sylvain Etter, Xing Han, Christie L Harman, G. Krammer, J. Schnabel, Cody L. Wilson, Sean V. Taylor
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Absence of mutagenic activity in the bacterial reverse mutation assay with pulegone and peppermint oil
The essential oil of peppermint and one of its natural constituents, (R)-(+)-pulegone, are approved flavorings added to food worldwide. (R)-(+)-Pulegone and peppermint oil were tested separately in two independent bacterial reverse mutation assays according to Organisation for Economic Co-operation and Development Guideline 471. Both flavorings did not produce any evidence of mutagenicity up to cytotoxic concentrations in either the presence or the absence of exogenous metabolic activation.
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