抗坏血酸在健康和疾病中的研究进展

Current Chemical Biology Pub Date : 2021-01-08 DOI:10.2174/2212796814666210108101834

Ashwini Alur, P. Das, Vinuth Chikkamath

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引用次数: 0

摘要

抗坏血酸是人体各种代谢活动所必需的一种必需营养素。通常，柑橘类水果、蔬菜和内脏肉都是维生素c的良好来源。它具有很强的抗氧化作用，是一种清除剂，可以抵御自由基氧。它还有助于恢复照片老化的皮肤。它通过与铜离子相互作用抑制酪氨酸酶来控制黑色素的色素沉着。它作为一种抗氧化剂与维生素E一起再生α -生育酚，从而延缓细胞损伤。抗坏血酸被去质子化形成抗坏血酸阴离子，有助于其抗氧化特性，并作为潜在的抗癌剂。它降低了错配修复缺陷的人类结肠癌细胞的突变率。抗坏血酸是一种植物化学物质，具有抗关节炎炎症的微量营养素。目前，挑战在于找到最稳定的配方来达到最佳效果，如图1所示。

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Ascorbic acid in Health and Disease: A Review

Ascorbic acid is an essential nutrient, and required for various metabolic activities in humans. Typically citrus fruits, vegetables and organ meat are good source of Vitamin C. It acts as strong antioxidant and act as a scavenger in defence against free radical oxygen species. It has also contributed to rejuvenate photo aged skin. It has ability to control the pigmentation of melanin by inhibiting the enzyme tyrosinase by interacting with copper ions. It serves as a coantioxidant with vitamin E to regenerate alpha tocopherol, thereby retards cellular damage. Ascorbic acid is deprotonated to form ascorbate anion, contributes to its prooxidant properties and act as a potential anti-cancer agent. It reduces the mutation rate in mismatch-repair deficient human colon cancer cells. Ascorbic acid is a phytochemical has micronutrients that act against the inflammation in arthritis. Currently, challenges lies finding most stable formulation for achieving optimum results as shown in Fig. 1.

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来源期刊

Current Chemical Biology Medicine-Biochemistry (medical)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems. Current Chemical Biology covers the following areas: Chemical Synthesis (Syntheses of biologically important macromolecules including proteins, polypeptides, oligonucleotides, oligosaccharides etc.; Asymmetric synthesis; Combinatorial synthesis; Diversity-oriented synthesis; Template-directed synthesis; Biomimetic synthesis; Solid phase biomolecular synthesis; Synthesis of small biomolecules: amino acids, peptides, lipids, carbohydrates and nucleosides; and Natural product synthesis).