糖尿病患者血脂异常与HbA1c水平的评价

R. Malathi, A. Fatima, Mohd Iqbal Ahmed
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摘要

糖尿病是一种由胰岛素分泌或作用缺陷引起的高血糖代谢疾病。糖化血红蛋白(HbA1C)是估计血糖指数最可靠的指标之一。糖尿病常伴有未确诊的血脂异常,其特征是甘油三酯水平升高,高密度脂蛋白水平降低,低密度脂蛋白(LDL)颗粒增加。糖尿病是动脉粥样硬化性心血管疾病(ASCVD)的重要危险因素。本研究的目的是将血脂参数与不同水平的HbA1c相关联,以评估血脂异常与糖尿病状态的关系。在泰伦加纳邦甘地医院的生物化学实验室进行了一项观察性研究。经知情同意后,分别从糖尿病患者和明显非糖尿病患者中抽取5ml静脉血,分别在普通管和EDTA管中采集。用甘油磷酸氧化酶过氧化物酶测定血清甘油三酯,用胆固醇氧化酶法测定血清胆固醇,用Beckmann Coulter AU 500直接清除率法测定血清HDL,用Bio-Rad D10高效液相色谱法测定HbA1c。根据HbA1c结果将90例患者分为3组。1组HbA1c < 5.6, 2组HbA1c 5.6-7, 3组HbA1c > 7。本研究显示,在HbA1c < 5.6的组1中,脂质谱没有变化。2组HbA1c在5.6-7之间,LDL胆固醇显著升高。HbA1c >7组LDL、血清甘油三酯明显升高。因此,我们可以得出结论,在血糖控制不良的情况下,血脂异常会增加,HbA1c的评估也可以作为糖尿病患者血脂异常的预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Dyslipidemia with HbA1c levels in Diabetes Mellitus
Diabetes is a metabolic disease which has hyperglycaemia resulting from defects in insulin secretion or action. HbA1C is one of the most reliable test used for estimation of glycaemic index. Diabetes is often accompanied by undiagnosed dyslipidaemia, characterized by increased triglyceride level, decreased high-density lipoprotein levels and increase in low-density lipoprotein (LDL) particles. Diabetes is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD). The purpose of this study was to correlate lipid parameters with different levels of HbA1c to assess dyslipidaemia with diabetic status. An observational study was conducted in biochemistry laboratory at Gandhi Hospital, Telangana.After informed consent, 5ml of venous blood sample was collected in plain tube and EDTA tube from diabetic and apparently non diabetic patients. Estimation of serum triglycerides was done by glycerol phosphate oxidase peroxidase, serum cholesterol by cholesterol oxidase method, serum HDL by direct clearance method in Beckmann Coulter AU 500 and HbA1c was estimated by high performance liquid chromatography in Bio-Rad D10.A total of 90 samples were divided into 3 groups according to their HbA1c results. Group 1 with HbA1c less than 5.6, Group 2 with HbA1c 5.6-7 and Group 3 with HbA1c more than 7.The present study showed no variation in the lipid profile in Group1 with HbA1c < 5.6. In Group 2 with HbA1c between 5.6-7, there was significant increase in LDL cholesterol. In Group 3 with HbA1c >7 there was marked increase in LDL, serum triglyceride. Hence we can conclude that dyslipidemia is increased in poor glycemic control and evaluation of HbA1c may also be used as a predictor of dyslipidaemia in diabetics.
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