对手性、主链修饰肽核酸的见解:性质和生物活性。

Artificial DNA: PNA & XNA Pub Date : 2014-12-15 Epub Date: 2016-01-11 DOI:10.1080/1949095X.2015.1107176
Maria Moccia, Mauro F A Adamo, Michele Saviano
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引用次数: 22

摘要

PNAs正在成为针对天然mirna的有用合成装置。特别地,本文描述了3类结构修饰的PNAs类似物,即α, β和γ,它们的不同之处在于它们的主干修饰。讨论了它们的模式和对天然核酸的结合亲和力以及它们作为潜在的miRNA结合物在药物化学中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Insights on chiral, backbone modified peptide nucleic acids: Properties and biological activity.

PNAs are emerging as useful synthetic devices targeting natural miRNAs. In particular 3 classes of structurally modified PNAs analogs are herein described, namely α, β and γ, which differ by their backbone modification. Their mode and binding affinity for natural nucleic acids and their use in medicinal chemistry as potential miRNA binders is discussed.

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