优化精神科药物治疗的治疗药物监测和药理学检测的最新进展

IF 0.1 Q4 OTORHINOLARYNGOLOGY
K. Rentsch
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引用次数: 0

摘要

精神科药物的治疗性药物监测以及药物遗传学检测在众多实验室中越来越频繁地进行。在这篇综述中,对2011年和2012年的文献进行了总结。德国AGNP(神经精神药理学和药物精神病学协会)的指南包含了解释药物浓度所需的所有信息。尿液中血清素的测定可以作为评估抗抑郁药物疗效的标志,并且利用正电子发射断层扫描已经建立了大脑中目标受体的占用与药物浓度之间的相关性。年龄对药物浓度的影响一直存在争议,此外,女性一直表现出较慢的代谢和较高的血清浓度。介绍了几种用于精神药物定量分析的液相色谱-质谱(LC-MS)/质谱多分析方法。所有方法都显示出良好的验证数据,但由于并非一个多分析物程序中的所有化合物都能进行最佳分析,因此一直存在一些化合物验证结果不太好的情况。在开精神科药物处方之前,通常不进行药物遗传学检测。除了其他因素外,这还依赖于缺少大型随机试验和缺乏标准化分析方法,而标准化分析方法可以识别整个遗传变异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An update on therapeutic drug monitoring and pharmacogenetic testing for the optimization of therapy with psychiatric medication
Abstract Therapeutic drug monitoring of psychiatric medication as well as pharmacogenetic testing is performed more and more frequently in numerous laboratories. In this review, a summary of the literature in the years 2011 and 2012 has been completed. The guidelines of the German AGNP (Association for Neuropsychopharmacology and Pharmacopsychiatry) contain all the information needed for the interpretation of drug concentrations. The determination of serotonin in urine could be a marker for the assessment of the response of antidepressants, and correlations between the occupancy of the target receptors in the brain and drug concentration have been established using positron emission tomography. The influence of age on drug concentrations has been controversially described, and additionally females have always showed a slower metabolism and higher serum concentrations. Several liquid chromatography-mass spectrometry (LC-MS)/MS multi-analyte procedures for the quantification of psychiatric medication have been described. All methods showed good validation data, but there have always been some compounds with less good validation results due to the fact that not all compounds of a multi-analyte procedure can be analyzed optimally. Pharmacogenetic testing is not routinely performed prior to the prescription of psychiatric medication. This relies, among other things, on missing large randomized trials and the absence of standardized analytical methods, which allow the identification of the whole genetic variability.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
1
审稿时长
>12 weeks
期刊介绍: Information not localized
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