用室温离子液体修饰碳陶瓷电极测定氯沙坦的电化学行为和伏安法

Sensor Letters Pub Date : 2020-04-01 DOI:10.1166/sl.2020.4223

Mahzad Firouzi, M. Giahi, M. Najafi, S. Homami, Seyed Husain Hashemi Mousavi

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引用次数: 0

摘要

本文提出了一种电化学传感器，用于测定药物制剂中的氯沙坦(LOS)。采用室温离子液体1-丁基-3-甲基咪唑六氟磷酸(bmm . pf6)制备了改性碳陶瓷电极(IL-CCE)。采用循环和线性扫描伏安法(CV和LSV)、计时电流法和电化学阻抗谱(EIS)技术进行了电化学研究。在优化条件下，阳极峰值电流随LOS浓度的增加而增大，线性动态范围为20 ~ 200 μM，检出限为11.7 μM (S/N = 3)。对片剂中的LOS进行了分析，得到了满意的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Electrochemical Behavior and Voltammetric Determination of Losartan Using Carbon Ceramic Electrode Modified with Room Temperature Ionic Liquid

Herein, an electrochemical sensor has been proposed for the determination of losartan (LOS) in pharmaceutical formulations. A room temperature ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate (BMIM.PF6) was applied to fabricate a modified carbon ceramic electrode (IL-CCE). The electrochemical studies were performed by the cyclic and linear sweep voltammetry (CV and LSV), chronoamperometry and electrochemical impedance spectroscopy (EIS) techniques. The anodic peak currents were increased with the LOS concentration and indicated a linear dynamic range from 20 to 200 μM and a detection limit of 11.7 μM (S/N = 3) under the optimized conditions. Satisfactory results were obtained by analysis of LOS in pharmaceutical tablets.

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来源期刊

Sensor Letters 工程技术-电化学

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The growing interest and activity in the field of sensor technologies requires a forum for rapid dissemination of important results: Sensor Letters is that forum. Sensor Letters offers scientists, engineers and medical experts timely, peer-reviewed research on sensor science and technology of the highest quality. Sensor Letters publish original rapid communications, full papers and timely state-of-the-art reviews encompassing the fundamental and applied research on sensor science and technology in all fields of science, engineering, and medicine. Highest priority will be given to short communications reporting important new scientific and technological findings.