阿枣籽和辛伐他汀对黄油喂养的非酒精性脂肪性肝病(NAFLD)小鼠模型的保肝作用

Farooq Sultan
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摘要

非酒精性脂肪性肝病(NAFLD)是高脂血症的一种危险并发症,可导致危及生命的肝炎和肝硬化。在国际上,非酒精性脂肪性肝病(NAFLD)在普通人群中的患病率为20%,而在美国的肥胖人群中患病率为75%。1对抗药物的副作用导致了对天然产物的研究,以寻找其治疗NAFLD的潜力。目的:本研究的目的是评价红枣籽和辛伐他汀对NAFLD的肝保护作用。研究地点和时间:研究在拉合尔大学保健所动物舍进行,6个月完成。材料与方法:取大鼠40只,随机分为5组,每组8只。1组为健康对照组,2组为疾病对照组。3、4、5组患者分别给予辛伐他汀10mg/kg/d,水溶阿吉瓦枣籽提取物8ml/kg/d,辛伐他汀5mg/kg/d与水溶阿吉瓦枣籽提取物4ml/kg/d联合用药。总研究时间为36天。前15天用于诱导高脂血症,其余21天给予治疗。于试验第0、15、36天分别测定血清总胆固醇(TC)、甘油三酯(TG)和肝功能(ALT、AST、ALP)。数据采用SPSS 23.0统计软件录入,采用单因素方差分析和事后塔基检验进行分析。p值小于0.05为显著性。结果:Ajwa枣籽水提液(ADSE)、辛伐他汀及其联合用药对NAFLD具有显著的TC、TG降低和肝保护作用。然而,单独用药比联合用药更有效。结论:红枣籽可用于NAFLD的治疗。关键词:红枣子,高脂血症,辛伐他汀
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hepatoprotective Effect of Ajwa Date Seed and Simvastatin in Non Alcoholic Fatty Liver Disease (NAFLD) Murine Model of Butter Fed Dyslipidemia
Introduction: Non-alcoholic fatty liver disease (NAFLD) is a dangerous complication of hyperlipidemia which may lead to life threatening hepatitis and hepatic cirrhosis. Internationally, Prevalence of non-alcoholic fatty liver disease (NAFLD) is 20% in general population while 75% in the obese population of USA.1 Side effects of allopathic drugs have led the research towards natural products to find out their potential for treatment of NAFLD. Aims & Objectives: Aim of this study was evaluation of hepatoprotective effects of Ajwa date seed and Simvastatin against NAFLD. Place and duration of study: Study was conducted at animal house of UHS, Lahore and completed in 6 months. Material & Methods: 40 rats were procured and segregated into 5 groups with 8 rats in each group. Group 1 was healthy control and group 2 was disease control. Group 3, 4 and 5 were administered Simvastatin 10mg/kg/day, aqueous Ajwa date seed extract (ADSE) 8ml/kg/day and combination of Simvastatin 5mg/kg/day and aqueous ADSE 4ml/kg/day respectively. Total study duration was 36 days. First 15 days were for induction of hyperlipidemia while treatment was given for remaining 21 days. Serum total cholesterol (TC), triglycerides (TG) and liver functions tests (Serum ALT, AST and ALP) were performed at day 0, 15 and 36 of study. Data was entered on SPSS 23.0 software and analyzed by one way ANOVA and post hoc tuckey’s tests. P-value of less than 0.05 was considered significant. Results: Aqueous Ajwa date seed extract (ADSE), Simvastatin and their combination showed significant TC and TG lowering and hepatoprotective effects against NAFLD. However, individual drugs were more effective than the combination. Conclusion: Ajwa date seed can be used for the treatment of NAFLD. Key words: Ajwa date seed, Hyperlipidemia, Simvastatin
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