马来酰亚胺环化UCS1025A和B骨架类似物的合成及其生物活性

IF 1.4 4区化学 Q3 CHEMISTRY, ORGANIC

Synlett Pub Date : 2022-01-27 DOI:10.1055/s-0040-1719876

M. Moloney, Lewis T. Ibbotson, Kirsten E. Christensen, M. Genov, Alexander Pretsch, D. Pretsch

{"title":"马来酰亚胺环化UCS1025A和B骨架类似物的合成及其生物活性","authors":"M. Moloney, Lewis T. Ibbotson, Kirsten E. Christensen, M. Genov, Alexander Pretsch, D. Pretsch","doi":"10.1055/s-0040-1719876","DOIUrl":null,"url":null,"abstract":"Application of a direct ring-closing approach which exploits an intramolecular aldol reaction with a ketene silyl acetal onto a remote imide function leading to the core skeleton of UCS1025A and B effectively provides access to small library of substituted analogues; of interest is their complete lack of antibacterial activity against MRSA (Gram+) and E. coli (Gram–) bacterial strains.","PeriodicalId":22319,"journal":{"name":"Synlett","volume":"1 1","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Skeletal Analogues of UCS1025A and B by Cyclization of Maleimides: Synthesis and Biological Activity\",\"authors\":\"M. Moloney, Lewis T. Ibbotson, Kirsten E. Christensen, M. Genov, Alexander Pretsch, D. Pretsch\",\"doi\":\"10.1055/s-0040-1719876\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Application of a direct ring-closing approach which exploits an intramolecular aldol reaction with a ketene silyl acetal onto a remote imide function leading to the core skeleton of UCS1025A and B effectively provides access to small library of substituted analogues; of interest is their complete lack of antibacterial activity against MRSA (Gram+) and E. coli (Gram–) bacterial strains.\",\"PeriodicalId\":22319,\"journal\":{\"name\":\"Synlett\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2022-01-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synlett\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0040-1719876\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synlett","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1055/s-0040-1719876","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 1

摘要

应用直接闭合环的方法，利用分子内醛与烯酮硅酰缩醛的反应在远端亚胺功能上导致UCS1025A和B的核心骨架，有效地提供了小取代类似物库的访问;令人感兴趣的是它们对MRSA(革兰氏+)和大肠杆菌(革兰氏-)菌株完全缺乏抗菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Skeletal Analogues of UCS1025A and B by Cyclization of Maleimides: Synthesis and Biological Activity

Application of a direct ring-closing approach which exploits an intramolecular aldol reaction with a ketene silyl acetal onto a remote imide function leading to the core skeleton of UCS1025A and B effectively provides access to small library of substituted analogues; of interest is their complete lack of antibacterial activity against MRSA (Gram+) and E. coli (Gram–) bacterial strains.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.