{"title":"超声显示脂肪肝征的青少年青春期激素和代谢特征(以阿尔汉格尔斯克为例)","authors":"S. Malyavskaya, A. Lebedev, G. Kostrova","doi":"10.17816/humeco109055","DOIUrl":null,"url":null,"abstract":"AIM: To establish the nature of hormonal and metabolic disorders and the relationship of atherogenic risk factors in puberty in adolescents with ultrasound signs of fatty hepatosis. \nMETHODS: A sample of 120 adolescents aged 1217 years from Arkhangelsk having instrumental signs of fatty hepatosis were examined for indicators of peroxidation, chronic inflammation and insulin resistance. A group of 219 adolescents from Arkhangelsk who did not have acute and chronic diseases at the time of examination were used as a comparison group. \nRESULTS: The results showed higher mean values of total C-reactive protein (2.76 mg/ml), lipid peroxidation (531.28 mmol/l), waist circumference (72.15 cm), body mass index (25.70 kg/m2), uric acid (0.29 mmol/l), HOMA index (2.24 IU), insulin (11.92 uIU/ml), triglycerides (0.91 mmol/l), and low-density lipoprotein cholesterol (2.20 mmol/l) in the group of adolescents with fatty hepatosis than in the comparison group (0.77 mg/ml, p 0.001; 371.19 mmol/l, p=0.027; 58.19 cm, p 0.001; 25.70 kg/m2, p 0.001; 0.25 mmol/l, p 0.001; 1.01 IU, p 0.001; 5.90 uIU/ml, p 0.001; 0.69 mmol/l, p 0.001; 2.06 mmol/l, p=0.025, respectively). \nCONCLUSION: These results confirm that the pathogenetic components of non-alcoholic fatty liver disease (insulin resistance, accompanied by hyperinsulinemia against the background of abdominal fat deposition, activation of lipid peroxidation, atherogenic dyslipidemia, hyperuricemia, and chronic inflammation) should be considered in adolescence in the prevention, diagnosis, monitoring, and treatment of non-alcoholic fatty liver disease.","PeriodicalId":38121,"journal":{"name":"Ekologiya Cheloveka (Human Ecology)","volume":" 40","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hormonal and metabolic features of puberty in adolescents with ultrasound signs of fatty hepatosis (on the example of Arkhangelsk)\",\"authors\":\"S. Malyavskaya, A. Lebedev, G. Kostrova\",\"doi\":\"10.17816/humeco109055\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"AIM: To establish the nature of hormonal and metabolic disorders and the relationship of atherogenic risk factors in puberty in adolescents with ultrasound signs of fatty hepatosis. \\nMETHODS: A sample of 120 adolescents aged 1217 years from Arkhangelsk having instrumental signs of fatty hepatosis were examined for indicators of peroxidation, chronic inflammation and insulin resistance. A group of 219 adolescents from Arkhangelsk who did not have acute and chronic diseases at the time of examination were used as a comparison group. \\nRESULTS: The results showed higher mean values of total C-reactive protein (2.76 mg/ml), lipid peroxidation (531.28 mmol/l), waist circumference (72.15 cm), body mass index (25.70 kg/m2), uric acid (0.29 mmol/l), HOMA index (2.24 IU), insulin (11.92 uIU/ml), triglycerides (0.91 mmol/l), and low-density lipoprotein cholesterol (2.20 mmol/l) in the group of adolescents with fatty hepatosis than in the comparison group (0.77 mg/ml, p 0.001; 371.19 mmol/l, p=0.027; 58.19 cm, p 0.001; 25.70 kg/m2, p 0.001; 0.25 mmol/l, p 0.001; 1.01 IU, p 0.001; 5.90 uIU/ml, p 0.001; 0.69 mmol/l, p 0.001; 2.06 mmol/l, p=0.025, respectively). \\nCONCLUSION: These results confirm that the pathogenetic components of non-alcoholic fatty liver disease (insulin resistance, accompanied by hyperinsulinemia against the background of abdominal fat deposition, activation of lipid peroxidation, atherogenic dyslipidemia, hyperuricemia, and chronic inflammation) should be considered in adolescence in the prevention, diagnosis, monitoring, and treatment of non-alcoholic fatty liver disease.\",\"PeriodicalId\":38121,\"journal\":{\"name\":\"Ekologiya Cheloveka (Human Ecology)\",\"volume\":\" 40\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ekologiya Cheloveka (Human Ecology)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17816/humeco109055\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Social Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ekologiya Cheloveka (Human Ecology)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17816/humeco109055","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Social Sciences","Score":null,"Total":0}
引用次数: 0
摘要
目的:探讨青春期脂肪性肝病超声征象与青春期激素代谢紊乱的性质及其与动脉粥样硬化危险因素的关系。方法:从阿尔汉格尔斯克选取120名年龄1217岁、有脂肪肝症状的青少年作为样本,检测其过氧化、慢性炎症和胰岛素抵抗指标。在检查时没有急性和慢性疾病的219名阿尔汉格尔斯克青少年被用作对照组。结果:青少年脂肪肝组总c反应蛋白(2.76 mg/ml)、脂质过氧化(531.28 mmol/l)、腰围(72.15 cm)、体重指数(25.70 kg/m2)、尿酸(0.29 mmol/l)、HOMA指数(2.24 IU)、胰岛素(11.92 IU/ml)、甘油三酯(0.91 mmol/l)、低密度脂蛋白胆固醇(2.20 mmol/l)的平均值均高于对照组(0.77 mg/ml, p 0.001);371.19 mmol/l, p=0.027;58.19 cm, p 0.001;25.70 kg/m2, p < 0.001;0.25 mmol/l, p 0.001;1.01 IU, p 0.001;5.90 uIU/ml, p 0.001;0.69 mmol/l, p 0.001;2.06 mmol/l, p=0.025)。结论:这些结果证实,非酒精性脂肪性肝病的发病因素(胰岛素抵抗,伴随腹部脂肪沉积的高胰岛素血症,脂质过氧化活化,动脉粥样硬化性血脂异常,高尿酸血症和慢性炎症)应在青少年预防,诊断,监测和治疗非酒精性脂肪性肝病时考虑。
Hormonal and metabolic features of puberty in adolescents with ultrasound signs of fatty hepatosis (on the example of Arkhangelsk)
AIM: To establish the nature of hormonal and metabolic disorders and the relationship of atherogenic risk factors in puberty in adolescents with ultrasound signs of fatty hepatosis.
METHODS: A sample of 120 adolescents aged 1217 years from Arkhangelsk having instrumental signs of fatty hepatosis were examined for indicators of peroxidation, chronic inflammation and insulin resistance. A group of 219 adolescents from Arkhangelsk who did not have acute and chronic diseases at the time of examination were used as a comparison group.
RESULTS: The results showed higher mean values of total C-reactive protein (2.76 mg/ml), lipid peroxidation (531.28 mmol/l), waist circumference (72.15 cm), body mass index (25.70 kg/m2), uric acid (0.29 mmol/l), HOMA index (2.24 IU), insulin (11.92 uIU/ml), triglycerides (0.91 mmol/l), and low-density lipoprotein cholesterol (2.20 mmol/l) in the group of adolescents with fatty hepatosis than in the comparison group (0.77 mg/ml, p 0.001; 371.19 mmol/l, p=0.027; 58.19 cm, p 0.001; 25.70 kg/m2, p 0.001; 0.25 mmol/l, p 0.001; 1.01 IU, p 0.001; 5.90 uIU/ml, p 0.001; 0.69 mmol/l, p 0.001; 2.06 mmol/l, p=0.025, respectively).
CONCLUSION: These results confirm that the pathogenetic components of non-alcoholic fatty liver disease (insulin resistance, accompanied by hyperinsulinemia against the background of abdominal fat deposition, activation of lipid peroxidation, atherogenic dyslipidemia, hyperuricemia, and chronic inflammation) should be considered in adolescence in the prevention, diagnosis, monitoring, and treatment of non-alcoholic fatty liver disease.