Facteurs étiologiques généraux de la pathologie pulpodentinaire

Some general pathologies may have consequences on dental pulp and dentin. The incidence of such diseases on pulp can be necrosis, calcification, and metaplasia. On dentin, an excess or a defect of dentinogenesis and/or mineralisation have been observed. A review of recent literature provides new information on the various pulp-dentinal pathologies and on the pathogenic mechanisms involved; these may be induced by poorly controlled diabetes mellitus, atherosclerosis, hyperbilirubinemia, chronic renal pathologies, oxalosis, anachoresis, disorders of parathyroid, hypervitaminosis D, scleroderma, certain malignant tumours, genetic diseases such as hereditary rickets, hypophosphatasia, osteogenesis imperfecta and various rare hereditary syndromes, dietetic ion and vitamin deficiencies, mercury intoxication, fungal infections with Candida, zona, leprosy, and various general treatments (glucocorticoids, tetracyclines, fluoride supplementation and anti-cancer therapy).