{"title":"血型- lxviii的免疫化学研究","authors":"Hlvin A. Kabat , Jerry Liao , Raymond U. Lemieux","doi":"10.1016/0161-5890(78)90100-1","DOIUrl":null,"url":null,"abstract":"<div><p>Oligosaccharide inhibition studies using anti-I Ma (group 1) showed that<span>d</span>Galβl → 4<span>d</span>GlcNAcβl → 6<span>d</span>Gal its βl → O-(CH<sub>2</sub>)<sub>8</sub>COOCH<sub>3</sub> glycoside and OG<em>R</em><sub><em>L</em></sub>1.1 (<span>d</span>Galβl → 4<span>d</span>GlcNAcβl → 6-3,4-dideoxy-hex-3-enitols) were equally active on a molar basis defining the anti-I Ma (group 1) site as complementary to<span>d</span>Galβl → 4<span>d</span>GlcNAcβl → OCH<sub>2</sub>-. The 1 → 3,1 → 6 compound showed very weak activity, the 1 → 4.1 → 3 and 1 → 3.1 → 3 compounds and the βl → O-(CH<sub>2</sub>)<sub>8</sub>COOCH<sub>3</sub> glycosides of these three latter compounds were inactive in the range studied. The anti-S XIV site differs from the anti-I Ma site in that<span>d</span>Galβl → 4<span>d</span>GlcNAcβl → 6<span>d</span>Gal was only slightly better than<span>d</span>Galβl → 4<span>d</span>GlcNAcβl → 3<span>d</span>Gal and both were only about 1–3 more active than<span>d</span>Galβl → 4<span>d</span>GlcNAc. All compounds were inactive in the amounts available (1–2 μ<em>M</em>) with anti-I Step and Nay (group 3), Phi and AJ (group 6) and anti-i Den.</p></div>","PeriodicalId":13265,"journal":{"name":"Immunochemistry","volume":"15 10","pages":"Pages 727-731"},"PeriodicalIF":0.0000,"publicationDate":"1978-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-5890(78)90100-1","citationCount":"41","resultStr":"{\"title\":\"Immunochemical studies on blood groups-LXVIII\",\"authors\":\"Hlvin A. Kabat , Jerry Liao , Raymond U. Lemieux\",\"doi\":\"10.1016/0161-5890(78)90100-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Oligosaccharide inhibition studies using anti-I Ma (group 1) showed that<span>d</span>Galβl → 4<span>d</span>GlcNAcβl → 6<span>d</span>Gal its βl → O-(CH<sub>2</sub>)<sub>8</sub>COOCH<sub>3</sub> glycoside and OG<em>R</em><sub><em>L</em></sub>1.1 (<span>d</span>Galβl → 4<span>d</span>GlcNAcβl → 6-3,4-dideoxy-hex-3-enitols) were equally active on a molar basis defining the anti-I Ma (group 1) site as complementary to<span>d</span>Galβl → 4<span>d</span>GlcNAcβl → OCH<sub>2</sub>-. The 1 → 3,1 → 6 compound showed very weak activity, the 1 → 4.1 → 3 and 1 → 3.1 → 3 compounds and the βl → O-(CH<sub>2</sub>)<sub>8</sub>COOCH<sub>3</sub> glycosides of these three latter compounds were inactive in the range studied. The anti-S XIV site differs from the anti-I Ma site in that<span>d</span>Galβl → 4<span>d</span>GlcNAcβl → 6<span>d</span>Gal was only slightly better than<span>d</span>Galβl → 4<span>d</span>GlcNAcβl → 3<span>d</span>Gal and both were only about 1–3 more active than<span>d</span>Galβl → 4<span>d</span>GlcNAc. All compounds were inactive in the amounts available (1–2 μ<em>M</em>) with anti-I Step and Nay (group 3), Phi and AJ (group 6) and anti-i Den.</p></div>\",\"PeriodicalId\":13265,\"journal\":{\"name\":\"Immunochemistry\",\"volume\":\"15 10\",\"pages\":\"Pages 727-731\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0161-5890(78)90100-1\",\"citationCount\":\"41\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0161589078901001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161589078901001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Oligosaccharide inhibition studies using anti-I Ma (group 1) showed thatdGalβl → 4dGlcNAcβl → 6dGal its βl → O-(CH2)8COOCH3 glycoside and OGRL1.1 (dGalβl → 4dGlcNAcβl → 6-3,4-dideoxy-hex-3-enitols) were equally active on a molar basis defining the anti-I Ma (group 1) site as complementary todGalβl → 4dGlcNAcβl → OCH2-. The 1 → 3,1 → 6 compound showed very weak activity, the 1 → 4.1 → 3 and 1 → 3.1 → 3 compounds and the βl → O-(CH2)8COOCH3 glycosides of these three latter compounds were inactive in the range studied. The anti-S XIV site differs from the anti-I Ma site in thatdGalβl → 4dGlcNAcβl → 6dGal was only slightly better thandGalβl → 4dGlcNAcβl → 3dGal and both were only about 1–3 more active thandGalβl → 4dGlcNAc. All compounds were inactive in the amounts available (1–2 μM) with anti-I Step and Nay (group 3), Phi and AJ (group 6) and anti-i Den.
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