7周龄雌性大鼠自发性高级别未分化乳腺癌

Q2 Medicine

Experimental and Toxicologic Pathology Pub Date : 2017-06-14 DOI:10.1016/j.etp.2017.01.006

Ana I. Faustino-Rocha , Adelina Gama , Paula A. Oliveira , Antonieta Alvarado , Rita Ferreira , Mário Ginja

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引用次数: 2

摘要

目前的工作描述了一只7周大的Sprague-Dawley雌性大鼠的罕见自发高级别癌症病例，该大鼠被纳入乳腺癌发生测定的对照组。在50天大时发现了肿块，它生长得很快，8天后将动物人道地处死。肿瘤位于左侧颈部，左侧下颌下腺和舌下腺附近。它柔软而略带红色，有几个窝点，里面有血迹。肿瘤PAS阴性，ER-α免疫染色。组织病理学和免疫组织化学数据提示乳腺高级别癌。这是首次报道在如此年轻的大鼠身上发生自发性乳腺肿瘤。

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A spontaneous high-grade undifferentiated mammary carcinoma in a seven-week-old female rat

The present work describes a rare case of a spontaneous high-grade carcinoma in a seven-week-old Sprague-Dawley female rat that had been included in the control group of an assay of mammary carcinogenesis. The mass was detected at 50 days of age, it grown quickly and the animal was humanely sacrificed eight days later. The tumor was located in the left cervical region, in the vicinity of the left submandibular and sublingual glands. It was soft and reddish and had several dens with a bloody content. The tumor was PAS negative and exhibited immunostaining for ER-α. The histopathologic and immunohistochemical data are suggestive of a high-grade carcinoma from mammary gland. It was the first report of a spontaneous mammary tumor in such a young rat.

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来源期刊

Experimental and Toxicologic Pathology 医学-病理学

CiteScore

2.08

自引率

0.00%

发文量

审稿时长

5.3 weeks

期刊介绍： Cessation. The international multidisciplinary journal is devoted to the publication of studies covering the whole range of experimental research on disease processes and toxicology including cell biological investigations. Its aim is to support progress in the interdisciplinary cooperation of researchers working in pathobiology, toxicology, and cell biology independent of the methods applied. During the past decades increasing attention has been paid to the importance of toxic influence in the pathogenesis of human and animal diseases. This is why Experimental and Toxicologic Pathology meets the urgent need for an interdisciplinary journal felt by a wide variety of experts in medicine and biology, including pathologists, toxicologists, biologists, physicians, veterinary surgeons, pharmacists, and pharmacologists working in academic, industrial or clinical institutions.