{"title":"在中国的高危人群中进行肝癌筛查未能降低死亡率","authors":"Sammy Saab MD, MPH (Commentary Author)","doi":"10.1016/j.ehbc.2004.05.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Question</h3><p>Does liver cancer screening reduce mortality from the disease in a high-risk Chinese population?</p></div><div><h3>Study design</h3><p>Cluster randomised controlled trial.</p></div><div><h3>Main results</h3><p>In people at high risk of liver cancer, screening did not significantly reduce the incidence of primary liver cancer or risk of death compared with no screening (see Table 1), despite earlier detection of the disease (see notes).<span><div><div><table><tbody><tr><td>Table 1 Primary liver cancer incidence and mortality rates in a high-risk Chinese population.</td></tr><tr><td></td><td>Screened (<span><math><mtext>N=3712</mtext></math></span>)</td><td>Not screened (<span><math><mtext>N=1869</mtext></math></span>)</td><td><span><math><mtext>p</mtext></math></span> value</td></tr><tr><td>Number of primary liver cancer cases</td><td>257 (7%)</td><td>117 (6%)</td><td></td></tr><tr><td>Incidence rate<sup>†</sup></td><td>1341</td><td>1195</td><td>0.30</td></tr><tr><td>Deaths from primary liver cancer</td><td>218 (6%)</td><td>109 (6%)</td><td></td></tr><tr><td>Mortality rate<sup>†</sup></td><td>1138</td><td>1113</td><td>0.86</td></tr></tbody></table></div></div></span> <sup>†</sup>Per 100,000 person years.</p></div><div><h3>Authors’ conclusions</h3><p>Liver cancer screening in a high-risk population in China does not reduce mortality from the disease.</p></div>","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"8 4","pages":"Pages 221-223"},"PeriodicalIF":0.0000,"publicationDate":"2004-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehbc.2004.05.003","citationCount":"2","resultStr":"{\"title\":\"Liver cancer screening in a high-risk population in China fails to reduce mortality\",\"authors\":\"Sammy Saab MD, MPH (Commentary Author)\",\"doi\":\"10.1016/j.ehbc.2004.05.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Question</h3><p>Does liver cancer screening reduce mortality from the disease in a high-risk Chinese population?</p></div><div><h3>Study design</h3><p>Cluster randomised controlled trial.</p></div><div><h3>Main results</h3><p>In people at high risk of liver cancer, screening did not significantly reduce the incidence of primary liver cancer or risk of death compared with no screening (see Table 1), despite earlier detection of the disease (see notes).<span><div><div><table><tbody><tr><td>Table 1 Primary liver cancer incidence and mortality rates in a high-risk Chinese population.</td></tr><tr><td></td><td>Screened (<span><math><mtext>N=3712</mtext></math></span>)</td><td>Not screened (<span><math><mtext>N=1869</mtext></math></span>)</td><td><span><math><mtext>p</mtext></math></span> value</td></tr><tr><td>Number of primary liver cancer cases</td><td>257 (7%)</td><td>117 (6%)</td><td></td></tr><tr><td>Incidence rate<sup>†</sup></td><td>1341</td><td>1195</td><td>0.30</td></tr><tr><td>Deaths from primary liver cancer</td><td>218 (6%)</td><td>109 (6%)</td><td></td></tr><tr><td>Mortality rate<sup>†</sup></td><td>1138</td><td>1113</td><td>0.86</td></tr></tbody></table></div></div></span> <sup>†</sup>Per 100,000 person years.</p></div><div><h3>Authors’ conclusions</h3><p>Liver cancer screening in a high-risk population in China does not reduce mortality from the disease.</p></div>\",\"PeriodicalId\":100512,\"journal\":{\"name\":\"Evidence-based Healthcare\",\"volume\":\"8 4\",\"pages\":\"Pages 221-223\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ehbc.2004.05.003\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Evidence-based Healthcare\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S146294100400083X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Evidence-based Healthcare","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S146294100400083X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Liver cancer screening in a high-risk population in China fails to reduce mortality
Question
Does liver cancer screening reduce mortality from the disease in a high-risk Chinese population?
Study design
Cluster randomised controlled trial.
Main results
In people at high risk of liver cancer, screening did not significantly reduce the incidence of primary liver cancer or risk of death compared with no screening (see Table 1), despite earlier detection of the disease (see notes).
Table 1 Primary liver cancer incidence and mortality rates in a high-risk Chinese population.
Screened ()
Not screened ()
value
Number of primary liver cancer cases
257 (7%)
117 (6%)
Incidence rate†
1341
1195
0.30
Deaths from primary liver cancer
218 (6%)
109 (6%)
Mortality rate†
1138
1113
0.86
†Per 100,000 person years.
Authors’ conclusions
Liver cancer screening in a high-risk population in China does not reduce mortality from the disease.