静脉注射硫酸镁不能改善中风患者的生存或残疾结果

Evidence-based Healthcare Pub Date : 2004-08-01 DOI:10.1016/j.ehbc.2004.05.002

Scott Selco MD, PhD (Commentary Author), Bruce Ovbiagele MD (Commentary Author)

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引用次数: 1

摘要

问题：如果在中风发作后12小时内给予静脉注射硫酸镁，是否能提高生存率或致残率？研究设计多中心随机对照试验。主要结果与安慰剂相比，静脉注射硫酸镁并没有显著改善中风患者90天的生存率或致残率（见表1）。表1中风患者90天后的生存率和致残率。安慰剂（N=1198）硫酸镁（N=1188）比值比（95%CI）P值死亡和致残的综合结果未报告未报告0.95（0.80至1.13）0.59死亡196（16.4%）227（19.1%）1.22（0.98至1.53）0.07Barthel评分<；95787（65.7%）775（65.2%）0.99（0.83-1.19）0.92Barthel评分<；60445（37.1%）449（37.8%）1.03（0.86至1.24）0.74改良Rankin评分>；1858（71.6%）826（69.5%）0.91（0.75至1.09）0.30作者的结论在中风后12小时内静脉注射硫酸镁不会改善生存率或残疾结果。

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Intravenous magnesium sulphate does not improve survival or disability outcomes in people with stroke

Question

Does intravenous magnesium sulphate improve survival or disability outcomes if given within 12 hours of stroke onset?

Study design

Multicentre randomised controlled trial.

Main results

Intravenous magnesium sulphate did not significantly improve survival or disability outcomes at 90 days compared with placebo in people with stroke (see Table 1).

Table 1 Survival and disability outcomes at 90 days in people with stroke.
	Placebo (N=1198)	Magnesium Sulphate (N=1188)	Odds Ratio (95% CI)	P value
Combined outcome of death and disability	Not reported	Not reported	0.95 (0.80 to 1.13)	0.59
Death	196 (16.4%)	227 (19.1%)	1.22 (0.98 to 1.53)	0.07
Barthel score <95	787 (65.7%)	775 (65.2%)	0.99 (0.83 to 1.19)	0.92
Barthel score <60	445 (37.1%)	449 (37.8%)	1.03 (0.86 to 1.24)	0.74
Modified Rankin score >1	858 (71.6%)	826 (69.5%)	0.91 (0.75 to 1.09)	0.30

Authors’ conclusions

Intravenous magnesium sulphate given within 12 hours of stroke does not improve survival or disability outcomes.

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Evidence-based Healthcare

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