超精细微血管成像检测斑块内新生血管的诊断准确性:一项系统综述和荟萃分析。

IF 2.1 3区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular diagnosis and therapy Pub Date : 2023-10-31 Epub Date: 2023-10-24 DOI:10.21037/cdt-23-202
Lina Zhao, Yubo Han, Yanling Che, Xuesong Zhang, Min Luo, Jinzhu Li
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引用次数: 0

摘要

背景:动脉粥样硬化斑块可导致颈动脉狭窄,“易损斑块”甚至可导致缺血性中风。本研究的目的是评估超精细微血管成像(SMI)检测动脉粥样硬化斑块患者颈动脉斑块内新生血管(IPN)的准确性。方法:检索Cochrane Library、Embase、Medline和Wanfang数据库至2023年1月17日。我们纳入了关于SMI诊断准确性的原始研究,用于评估颈动脉IPN。主要结果是SMI检测颈动脉IPN的准确性。进行荟萃分析以估计每个参数的准确性。我们使用诊断准确性研究的质量评估(QUADAS-2)来评估每篇纳入文章的偏倚风险。进行荟萃回归以确定可能导致测试敏感性或特异性异质性的项目。结果:该荟萃分析包括20项研究,涉及1225名患者的1589个颈动脉斑块。分析显示,SMI检测IPN的敏感性和特异性分别为93%[95%置信区间(CI):87-96%]和80%(95%置信区间:71-87%)。QUADAS-2结构域的偏倚风险较低。只有血脂异常的比例影响敏感性和特异性的估计。结论:本综述表明SMI对颈动脉IPN具有良好的诊断性能。SMI具有非常高的灵敏度和极好的测试后概率,这表明SMI可以被推荐用于筛查颈动脉斑块患者的颈动脉IPN。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Diagnostic accuracy of superb microvascular imaging for detecting intraplaque neovascularization: a systematic review and meta-analysis.

Diagnostic accuracy of superb microvascular imaging for detecting intraplaque neovascularization: a systematic review and meta-analysis.

Diagnostic accuracy of superb microvascular imaging for detecting intraplaque neovascularization: a systematic review and meta-analysis.

Diagnostic accuracy of superb microvascular imaging for detecting intraplaque neovascularization: a systematic review and meta-analysis.

Background: Atherosclerotic plaques can cause carotid artery stenosis, and "vulnerable plaques" can even lead to ischemic stroke. The objective of this study was to assess the accuracy of superb microvascular imaging (SMI) for the detection of carotid intraplaque neovascularization (IPN) in patients with atherosclerotic plaques.

Methods: We searched the Cochrane Library, Embase, Medline, and Wanfang databases until January 17, 2023. We included original studies with information on diagnostic accuracy of SMI for the evaluation of carotid IPN. The primary outcome was the accuracy of SMI for detecting carotid IPN. A meta-analysis was performed to estimate the accuracy of each parameter. We used the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) to assess the risk of bias for each included article. Meta-regression was performed to determine items that may have contributed to heterogeneity in the sensitivity or specificity of the test.

Results: This meta-analysis included 20 studies with 1,589 carotid plaques in 1,225 patients. The analysis showed a sensitivity and specificity of SMI for detecting IPN of 93% [95% confidence interval (CI): 87-96%] and 80% (95% CI: 71-87%), respectively. The risk of bias across the QUADAS-2 domains was low. Only the proportion of dyslipidemia influenced the estimates of sensitivity and specificity.

Conclusions: This review suggests that SMI has a good diagnostic performance for detecting carotid IPN. The very high sensitivity with excellent post-test probability indicated that SMI can be recommended to screen for carotid IPN among patients with carotid plaques.

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来源期刊
Cardiovascular diagnosis and therapy
Cardiovascular diagnosis and therapy Medicine-Cardiology and Cardiovascular Medicine
CiteScore
4.90
自引率
4.20%
发文量
45
期刊介绍: The journal ''Cardiovascular Diagnosis and Therapy'' (Print ISSN: 2223-3652; Online ISSN: 2223-3660) accepts basic and clinical science submissions related to Cardiovascular Medicine and Surgery. The mission of the journal is the rapid exchange of scientific information between clinicians and scientists worldwide. To reach this goal, the journal will focus on novel media, using a web-based, digital format in addition to traditional print-version. This includes on-line submission, review, publication, and distribution. The digital format will also allow submission of extensive supporting visual material, both images and video. The website www.thecdt.org will serve as the central hub and also allow posting of comments and on-line discussion. The web-site of the journal will be linked to a number of international web-sites (e.g. www.dxy.cn), which will significantly expand the distribution of its contents.
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