Rimegepant治疗偏头痛患者的疗效和安全性：随机对照研究的荟萃分析。

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropharmacology Pub Date : 2024-01-01 Epub Date: 2023-11-01 DOI:10.1097/WNF.0000000000000576

Chao Yang, Yue Zhang

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引用次数: 0

摘要

目的：利美泮可能在治疗偏头痛方面具有一定的潜力，本荟萃分析旨在研究利美泮治疗偏头痛患者的疗效和安全性。方法：我们检索了包括PubMed、Embase、Web of Science、EBSCO和Cochrane Library数据库在内的多个数据库，并选择了比较利美潘与安慰剂对偏头痛患者疗效的随机对照试验。这项荟萃分析是使用基于异质性的随机或固定效应模型进行的。结果：本荟萃分析包括三项随机对照试验。在偏头痛患者中，与安慰剂相比，利美泮治疗显著改善了2小时的疼痛自由度（比值比[OR]，2.10；95%置信区间[CI]，1.69-2.59；P<0.00001），2小时疼痛缓解（OR，1.93；95%CI，1.65-2.25；P<.00001），2小时功能正常（OR，1.69；95%可信区间，1.42-2001；P＜0.00001），24小时持续无痛（OR，2.88；95%置信区间，1.74-4.78；P＜.0001），24 h持续疼痛缓解（OR，2.31；95%CI，1.96-2.72；P＜0.001），无抢救药物（OR，2.42；95%可信区间，2.02-2.90；P＜0.00001），但对不良事件无明显影响（OR，1.27；95%置信区间，1.01-1.60；P＝0.04）。

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Efficacy and Safety of Rimegepant for Migraine Patients: A Meta-analysis of Randomized Controlled Studies.

Objectives: Rimegepant may have some potential in treating migraine, and this meta-analysis aims to study the efficacy and safety of rimegepant for migraine patients.

Methods: We have searched several databases including PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases and selected the randomized controlled trials comparing the efficacy of rimegepant versus placebo for migraine patients. This meta-analysis was conducted using the random- or fixed-effect model based on the heterogeneity.

Results: Three randomized controlled trials were included in this meta-analysis. Compared with placebo in migraine patients, rimegepant treatment was associated with substantially improved freedom from pain at 2 hours (odds ratio [OR], 2.10; 95% confidence interval [CI], 1.69-2.59; P < 0.00001), pain relief at 2 hours (OR, 1.93; 95% CI, 1.65 to 2.25; P < 0.00001), freedom from the most bothersome symptom at 2 hours (OR, 1.61; 95% CI, 1.35-1.91; P < 0.00001), ability to function normally at 2 hours (OR, 1.69; 95% CI, 1.42-2.01; P < 0.00001), sustained freedom from pain at 24 hours (OR, 2.88; 95% CI, 1.74-4.78; P < 0.0001), sustained pain relief at 24 hours (OR, 2.31; 95% CI, 1.96-2.72; P < 0.00001), and no rescue medication (OR, 2.42; 95% CI, 2.02-2.90; P < 0.00001) but showed no obvious impact on adverse events (OR, 1.27; 95% CI, 1.01-1.60; P = 0.04).

Conclusions: Rimegepant may be effective and safe for the treatment of migraine patients.

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.