在一项随机对照试验中,补充维生素D和阳光照射可维持孕妇血压并增加出生体重。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Rita Dewi Sunarno, Martha Irene Kartasurya, Ari Suwondo, Mohammad Zen Rahfiludin
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引用次数: 0

摘要

背景:补充维生素D或暴露在阳光下会增加孕妇的钙二醇水平,降低血压并增加出生体重。我们旨在比较阳光照射和补充维生素D对孕妇钙二醇水平、血压和新生儿人体测量指数的影响。方法:本随机临床试验于2021年旱季在印度尼西亚三宝垄市对108名妊娠20周的孕妇进行。受试者被随机均匀地分为3组,每组36名受试者(阳光照射、维生素D补充和对照组)。维生素D组每天服用1000 IU,阳光照射组建议每周服用3次15-30分钟,持续17周。通过家访每2天监测一次合规性。干预前后比较各组的降钙二醇水平和血压。比较各组之间的增量和新生儿人体测量指数,并控制混杂因素。结果:在基线时,所有组都有维生素D缺乏,不同的平均钙二醇水平,收缩压和舒张压。干预后,阳光照射组和维生素D组的平均钙二醇水平增加。仅维生素D组收缩压下降(P=0.019)。与阳光照射组(3091±362.5g)和对照组(2861±208.0g)相比,维生素D组的平均出生体重最高(3172±181.8 g)。结论:补充维生素D和暴露在阳光下可增加钙二醇水平和出生体重。补充维生素D可以维持收缩压。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitamin D Supplementation and Sun Exposure Maintain Blood Pressures of Pregnant Women and Increase Birth Weight in a Randomized Controlled Trial.

Background: Vitamin D supplementation or sun exposure increase pregnant women's Calcidiol levels, lower the blood pressures and increase birth weight. We aimed to compare the effects between sun exposure and vitamin D supplementation on pregnant women's Calcidiol levels, blood pressures and newborns' anthropometric indices.

Methods: This randomized clinical trial was conducted on 108 pregnant women at 20 wk of gestation on 2021's dry season in Semarang City, Indonesia. The subjects were randomly and evenly divided into 3 groups of 36 subjects (sunlight exposure, vitamin D supplement, and control). Vitamin D group received 1000 IU daily and sun exposure group was recommended to have 15-30 min for 3 times/week for 17 wk. Compliance was monitored every 2 d through home visits. Calcidiol levels, blood pressures, in all groups were compared before and after intervention. The increments and the newborn anthropometric indices were compared between the groups and controlled for confounding factors.

Results: At baseline, all groups had vitamin D deficiency, different mean Calcidiol levels, systolic, and diastolic blood pressures. The mean Calcidiol levels increased in the sun exposure and vitamin D group after the intervention. Systolic blood pressure decreased in the vitamin D group only (P=0.019). The mean birth weight was the highest in the vitamin D group (3,172±181.8 g) compared to the sun exposure (3,091±362.5g) and control groups (2,861 ± 208.0 g).

Conclusion: Vitamin D supplementation and sun exposure increased Calcidiol levels and birth weights. Vitamin D supplementation maintained systolic blood pressure.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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