产前邻苯二甲酸二甲氧基乙酯暴露损害小鼠皮层神经发生和突触活动。

IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Brain Pathology Pub Date : 2023-10-30 DOI:10.1111/bpa.13221
Moon Yi Ko, Heejin Park, Sun-Hwa Chon, Byoung-Seok Lee, Sin-Woo Cha, Sung-Ae Hyun, Minhan Ka
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引用次数: 0

摘要

邻苯二甲酸二甲氧基乙酯(DMEP)是一种常见的环境内分泌干扰物,可能与神经发育障碍有关,包括注意力缺陷/多动障碍和智力残疾。然而,导致这些神经发育障碍的调节机制仍然知之甚少。在这里,我们证明了产前DMEP暴露会导致小鼠大脑形态和功能异常。DMEP(50 mg/kg)从胚胎第0天(E0)开始每天口服一次,直至停止对胎儿的母乳喂养。我们发现,产前DMEP暴露通过损害发育中皮层的神经发生和胶质生成,显著减少了顶叶皮层的神经元数量。此外,我们发现产前DMEP暴露损害了顶叶皮层的树突棘结构和突触活动。最后,小鼠产前接触DMEP可诱导多动并减少焦虑行为。总之,我们的研究表明,产前DMEP暴露通过神经发生和突触活动受损导致异常行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prenatal Di-methoxyethyl phthalate exposure impairs cortical neurogenesis and synaptic activity in the mice

Prenatal Di-methoxyethyl phthalate exposure impairs cortical neurogenesis and synaptic activity in the mice

Prenatal Di-methoxyethyl phthalate exposure impairs cortical neurogenesis and synaptic activity in the mice

Di-methoxyethyl phthalate (DMEP) is a well-known environmentally prevalent endocrine disruptor and may be associated with neurodevelopmental disorders including attention deficit/hyperactivity disorder and intellectual disability. However, the regulatory mechanisms leading to these neurodevelopmental disorders are still poorly understood. Here, we demonstrate that prenatal DMEP exposure causes abnormal brain morphology and function in the mice. DMEP (50 mg/kg) was chronically administered to pregnant mice orally once a day starting on embryonic day 0 (E0) to breast-feeding cessation for the fetus. We found that prenatal DMEP exposure significantly reduced the number of neurons in the parietal cortex by impairing neurogenesis and gliogenesis during the developing cortex. Moreover, we found that prenatal DMEP exposure impaired dendritic spine architectures and synaptic activity in the parietal cortex. Finally, prenatal DMEP exposure in mice induces hyperactivity and reduces anxiety behaviors. Altogether, our study demonstrates that prenatal DMEP exposure leads to abnormal behaviors via impairment of neurogenesis and synaptic activity.

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来源期刊
Brain Pathology
Brain Pathology 医学-病理学
CiteScore
13.20
自引率
3.10%
发文量
90
审稿时长
6-12 weeks
期刊介绍: Brain Pathology is the journal of choice for biomedical scientists investigating diseases of the nervous system. The official journal of the International Society of Neuropathology, Brain Pathology is a peer-reviewed quarterly publication that includes original research, review articles and symposia focuses on the pathogenesis of neurological disease.
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