人类新生儿心脏中的干细胞标记物

IF 0.3 Q4 PEDIATRICS

Journal of Pediatric and Neonatal Individualized Medicine Pub Date : 2016-07-08 DOI:10.7363/050204

A. Faa, E. Podda, V. Fanos

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引用次数: 4

摘要

哺乳动物心脏祖细胞的鉴定提高了人类心脏含有能够产生心肌细胞和冠状血管的干细胞群的可能性。最近的几项研究表明，成年人心脏的不同细胞类型来自一个共同的祖先。人类心脏干细胞分化为心肌细胞，并在较小程度上分化为平滑肌细胞和内皮细胞。人类心脏干细胞(CSCs)的表征具有重要的临床意义。近年来，CD117 (c-kit)被报道标记人类心脏中的一种干细胞/祖细胞亚型，具有干细胞样特性，包括自我更新能力和克隆原性多潜能。第二届围产期病理学国际课程论文集(第11届新生儿国际研讨会的一部分·2015年10月26日至31日)·卡利亚里(意大利)·2015年10月31日·干细胞:现在和未来客座编辑:Gavino Faa, Vassilios Fanos, Antonio Giordano

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Stem cell markers in the heart of the human newborn

The identification of cardiac progenitor cells in mammals raises the possibility that the human heart contains a population of stem cells capable of generating cardiomyocytes and coronary vessels. Several recent studies now show that the different cell types that characterize the adult human heart arise from a common ancestor. Human cardiac stem cells differentiate into cardiomyocytes, and, in lesser extent, into smooth muscle and endothelial cells. The characterization of human cardiac stem cells (CSCs) has important clinical implications. In recent years, CD117 (c-kit) has been reported to mark a subtype of stem/progenitor cells in the human heart, with stem cell-like properties, including the ability to self-renewal and clonogenicity multipotentiality. Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano

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来源期刊

Journal of Pediatric and Neonatal Individualized Medicine PEDIATRICS-

CiteScore

1.00

自引率

25.00%

发文量

审稿时长

12 weeks

期刊介绍： The Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) is a peer-reviewed interdisciplinary journal which provides a forum on new perspectives in pediatric and neonatal medicine. The aim is to discuss and to bring readers up to date on the latest in research and clinical pediatrics and neonatology. Special emphasis is on developmental origin of health and disease or perinatal programming and on the so-called ‘-omic’ sciences. Systems medicine blazes a revolutionary trail from reductionist to holistic medicine, from descriptive medicine to predictive medicine, from an epidemiological perspective to a personalized approach. The journal will be relevance to clinicians and researchers concerned with personalized care for the newborn and child. Also medical humanities will be considered in a tailored way. Article submission (original research, review papers, invited editorials and clinical cases) will be considered in the following fields: fetal medicine, perinatology, neonatology, pediatrics, developmental programming, psychology and medical humanities.