食道癌前病变和恶性病变的临床病理研究-横断面研究

K. Kala, G. Sarumathy, A. Prathiba
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引用次数: 0

摘要

食管癌是癌症相关死亡的第六大原因,在世界所有恶性肿瘤中排名第八。食管癌的发生与多种因素有关。目的:探讨食管癌前病变和恶性病变的临床病理特点,包括年龄、性别、危险因素、肿瘤部位、组织学类型、分级和分期。材料和方法:这是一项2013年6月至2014年6月在某三级保健中心病理学部进行的食管癌前病变和恶性病变的前瞻性研究。获得了病例的完整历史,包括调查和所做程序的类型。制备血红素和伊红(H&E)染色切片,分析报告的癌前病变和恶性病变的组织病理学参数。结果:本研究共纳入187例,其中恶性肿瘤177例(83.49%),癌前病变10例(5.34%)。食管癌的平均年龄为56.4岁,癌前病变的平均年龄为50.7岁。总体上,男性占主导地位。大多数恶性病变位于食管中部三分之一。最常见的组织学类型为鳞状细胞癌(SCC)(89.27%),其次为腺癌(9.6%)和神经内分泌癌(NEC)(1.13%)。最常见的肉眼类型为溃疡型(50.8%)。大多数病例出现在IIA期(74%)。25.92%的SCC病例和33.33%的腺癌病例存在淋巴结累及。结论:在本研究中,SCC是最常见的组织学类型,发病率在51-60岁之间达到高峰。吞咽困难是最常见的临床主诉,烟草是主要的危险因素。食管癌在本地区相当常见。然而,由于缺乏意识和延迟症状,大多数患者出现在晚期,给管理带来了重大挑战。因此,必须进行彻底的检查,包括组织病理学检查,特别是老年患者,以尽早排除食管癌,因为其预后与组织学类型、分级和分期密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Clinicopathological Study of Premalignant and Malignant Lesions of Oesophagus- A Cross-sectional Study
Introduction: Oesophageal cancer is the sixth leading cause of cancer related mortality and it ranks eighth among all malignancies in the world.There are multiple factors involved in the causation of oesophageal carcinoma. Aim: To study the clinicopathological features of premalignant and malignant lesions of oesophagus including age, sex, risk factors, tumour location, histological type, grade and stage. Materials and Methods: This is a prospective study of premalignant and malignant lesions of oesophagus conducted at Department of Pathology in a tertiary care centre from June 2013 to June 2014. Complete history of the cases including investigations and type of procedure done were obtained. Haematoxylin and Eosin (H&E) stained sections were prepared and cases reported as premalignant and malignant lesions were analysed for histopathological parameters. Results: In the present study, 187 cases were studied, of which, malignant tumors accounted for 177 cases (83.49%) while premalignant lesions were 10 cases (5.34%). The mean age of oesophageal cancer is 56.4 years and that for premalignant lesions is 50.7 years. Overall male predominance was noted. Most of the malignant lesions were located in the middle third of the oesophagus. Most common histological type was squamous cell carcinoma (SCC) (89.27%) followed by Adenocarcinoma (9.6%) and Neuroendocrine Carcinoma (NEC) (1.13%). The most common macroscopic type was ulcerative type (50.8%). Most of the cases presented in stage IIA (74%). Lymph node involvement was present in 25.92% of cases of SCC and 33.33% of cases of adenocarcinoma. Conclusion: In the present study, SCC was the commonest histological type with peak incidence in 51-60 years. Dysphagia was the most common clinical complaint with tobacco being the major risk factor. Esophageal carcinoma was quite common in this region. However majority of the patients presented at advanced stage due to lack of awareness and delayed symptoms causing major challenge in management. Hence, thorough investigations including histopathological examination is mandatory especially in older patients to rule out carcinoma oesophagus at the earliest, as the prognosis highly depends on histological type, grade and stage.
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