内镜下胃肠道活检的组织病理学谱:来自印度北阿坎德邦三级保健中心的经验

N. Bahal, A. Malviya, S. Ahuja
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引用次数: 0

摘要

胃肠道(GIT)是许多从炎症到恶性的病理病变的部位。内镜下活检在早期癌症和前驱病变的检测中起着重要的作用。它还有助于确定疾病的程度,监测对治疗的反应和早期发现并发症。然而,组织病理学评估是诊断的金标准,并有助于临床医生决定进一步的治疗。目的:确定胃肠道病变的组织病理学谱,并评估在印度北部三级保健中心胃肠道良性和恶性肿瘤的频率。材料和方法:这是一项回顾性研究,其中检索了2015年1月至2017年12月在Shri Guru Ram Rai医学与健康科学研究所病理学部收到的所有内镜下胃肠道活检。口咽部、食道、胃、小肠、大肠、直肠和肛管病变分为肿瘤(进一步分为良性和恶性)和非肿瘤。结果以频率和百分比表示。结果:867例患者中,男性582例,女性285例,男女比例为2.1:1。最常见的年龄组是60岁,平均年龄为53.8岁。在总共收到的7782例标本中,867例(11.1%)为内镜下胃肠道活检。其中口咽活检116例(13.4%),食管活检55例(6.3%),胃及胃食管交界区活检97例(11.2%),小肠活检138例(15.9%),结直肠及肛管活检461例(53.2%)。867例活检中670例(77.3%)为非肿瘤性,197例(22.7%)为肿瘤性。胃和口咽活检的恶性肿瘤发生率最高(29%),小肠活检的恶性肿瘤发生率最低(4.3%)。结论:在目前的研究中,鳞状细胞癌和溃疡性结肠炎分别是最常见的肿瘤和非肿瘤病变。建议将内窥镜检查结果与组织病理学相联系,以得出最终诊断并帮助临床医生进一步治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histopathological Spectrum of Endoscopic Gastrointestinal Biopsies: An Experience from a Tertiary Care Centre, Uttarakhand, India
Introduction: The Gastrointestinal Tract (GIT) is the site of numerous pathological lesions from inflammatory to malignant. Endoscopic biopsy plays an important role in detection of early- stage cancers and precursor lesions. It also aids in determining the extent of disease, monitoring response to therapy and for early detection of complications. However, histopathological evaluation serves as gold standard for diagnosis and aids the clinician in deciding further management. Aim: To determine the histopathological spectrum of gastrointestinal lesions and assess the frequency of benign and malignant tumours in GIT in a tertiary care center in North India. Materials and Methods: It was a retrospective study in which all endoscopic gastrointestinal biopsies received in Department of Pathology at Shri Guru Ram Rai Institute of Medical and Health Sciences from January 2015 to December 2017 were retrieved. The lesions from oropharynx, oesophagus, stomach, small intestine, large intestine, rectum and anal canal were categorised as neoplastic (further divided as benign and malignant) and non neoplastic. The results were tabulated and expressed as frequencies and percentages. Results: Of the 867 cases, 582 were males and 285 were females with a male to female ratio of 2.1:1. The most common age group was sixth decade with a mean age of 53.8 years. Out of a total of 7782 specimens received, 867 (11.1%) were endoscopic gastrointestinal biopsies. Among all the biopsies evaluated, 116 (13.4%) were from oropharynx, 55 (6.3%) oesophageal, 97 (11.2%) from stomach and Gastro-Oesophageal (GE) junction, 138 (15.9%) small intestinal and 461 (53.2%) from colorectum and anal canal. Out of 867 biopsies, 670 (77.3%) were classified as non neoplastic and 197 (22.7%) were neoplastic. Incidence of malignancy was highest in gastric (29%) and oropharyngeal (28.4%) biopsies while it was least in small intestinal biopsies (4.3%). Conclusion: In the current study, squamous cell carcinoma and ulcerative colitis were the most prevalent neoplastic and non neoplastic lesions, respectively. It is advisable to interpret and correlate endoscopic findings with histopathology to arrive at a final diagnosis and aid the clinician for further management.
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