原发性结外非霍奇金淋巴瘤:印度北部三级保健教学中心的一项观察性研究

Mili Jain, Shivanjali Raghuvanshi, S. Bhalla, P. Agarwal, Ashutosh Kumar, U. Singh, M. Goel
{"title":"原发性结外非霍奇金淋巴瘤:印度北部三级保健教学中心的一项观察性研究","authors":"Mili Jain, Shivanjali Raghuvanshi, S. Bhalla, P. Agarwal, Ashutosh Kumar, U. Singh, M. Goel","doi":"10.7860/njlm/2022/50589.2583","DOIUrl":null,"url":null,"abstract":"Introduction: Extranodal Non-Hodgkin’s Lymphoma (NHL) constitutes approximately one fourth of all NHL. The data regarding extranodal NHL from India is however limited. Aim: To evaluate the epidemiological and histomorphological patterns of extranodal NHL in a tertiary care institute in Northern India. Materials and Methods: The retrospective observational study was conducted on data of biopsy sections retrieved from the archives for a period of four years (January 2016 to December 2019), 130 extranodal NHL cases (90 males, 40 females) that were analysed for histological features and immunohistochemical subtype. All statistical analysis was done by Statistical Package for Social Sciences (SPSS) software. The values were represented in number, percentage, mean and ratio. Results: Total of 362 cases of NHL were reported. Out of which, 130 (36%) cases were of extranodal NHL. Male to female ratio being was 2.25:1. Mean age of presentation was 38.5 years. Paediatric cases constituted (32/130; 24.6%) cases. Head and neck was the most common site (52/130; 40%) followed by Gastrointestinal Tract (GIT) (21/130; 16.2%) and central nervous system (13/130; 10%). Amongst the paediatric cases, head and neck (11/32; 34.4%) was the most common site, followed by GIT (8/32; 25%). Amongst head and neck lymphomas, nasal cavity and Waldeyer Ring were the most common sites followed by orbit and oral cavity. Common sites among the GIT lymphomas were stomach, small intestine and large intestine. The B-cell NHL constituted 81/130 (62.3%), T-cell NHL 20/130 (15.4%) and NHL (Unclassified) were 29/130 (22.3%). Amongst B-cell type NHL, Diffuse Large B Cell Lymphoma (DLBCL) was the most common subtype. Conclusion: Extranodal NHL diagnosis is challenging due to morphological similarities with non haematopoietic tumours. Lineage determination by Immunohistochemistry (IHC) serves as the key to diagnosis. In our population, head and neck was the most common site, with B-cell NHL being the most common subtype.","PeriodicalId":31115,"journal":{"name":"National Journal of Laboratory Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Primary Extranodal Non-Hodgkin’s Lymphoma: An Observational Study at a Tertiary Care Teaching Centre in Northern India\",\"authors\":\"Mili Jain, Shivanjali Raghuvanshi, S. Bhalla, P. Agarwal, Ashutosh Kumar, U. Singh, M. Goel\",\"doi\":\"10.7860/njlm/2022/50589.2583\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Extranodal Non-Hodgkin’s Lymphoma (NHL) constitutes approximately one fourth of all NHL. The data regarding extranodal NHL from India is however limited. Aim: To evaluate the epidemiological and histomorphological patterns of extranodal NHL in a tertiary care institute in Northern India. Materials and Methods: The retrospective observational study was conducted on data of biopsy sections retrieved from the archives for a period of four years (January 2016 to December 2019), 130 extranodal NHL cases (90 males, 40 females) that were analysed for histological features and immunohistochemical subtype. All statistical analysis was done by Statistical Package for Social Sciences (SPSS) software. The values were represented in number, percentage, mean and ratio. Results: Total of 362 cases of NHL were reported. Out of which, 130 (36%) cases were of extranodal NHL. Male to female ratio being was 2.25:1. Mean age of presentation was 38.5 years. Paediatric cases constituted (32/130; 24.6%) cases. Head and neck was the most common site (52/130; 40%) followed by Gastrointestinal Tract (GIT) (21/130; 16.2%) and central nervous system (13/130; 10%). Amongst the paediatric cases, head and neck (11/32; 34.4%) was the most common site, followed by GIT (8/32; 25%). Amongst head and neck lymphomas, nasal cavity and Waldeyer Ring were the most common sites followed by orbit and oral cavity. Common sites among the GIT lymphomas were stomach, small intestine and large intestine. The B-cell NHL constituted 81/130 (62.3%), T-cell NHL 20/130 (15.4%) and NHL (Unclassified) were 29/130 (22.3%). Amongst B-cell type NHL, Diffuse Large B Cell Lymphoma (DLBCL) was the most common subtype. Conclusion: Extranodal NHL diagnosis is challenging due to morphological similarities with non haematopoietic tumours. Lineage determination by Immunohistochemistry (IHC) serves as the key to diagnosis. In our population, head and neck was the most common site, with B-cell NHL being the most common subtype.\",\"PeriodicalId\":31115,\"journal\":{\"name\":\"National Journal of Laboratory Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"National Journal of Laboratory Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7860/njlm/2022/50589.2583\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"National Journal of Laboratory Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7860/njlm/2022/50589.2583","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

结外非霍奇金淋巴瘤(NHL)约占所有NHL的四分之一。然而,来自印度的结外NHL数据有限。目的:评估结外NHL在印度北部三级医疗机构的流行病学和组织学模式。材料与方法:回顾性观察研究从2016年1月至2019年12月的4年档案中检索的130例结外NHL(男性90例,女性40例)的活检切片数据,分析其组织学特征和免疫组织化学亚型。所有统计分析均采用SPSS (statistical Package for Social Sciences)软件进行。数值以数字、百分比、平均值和比率表示。结果:共报告NHL病例362例。其中,130例(36%)为结外NHL。男女比例为2.25:1。平均出现年龄为38.5岁。儿科病例占32/130;24.6%)的病例。头颈部是最常见的部位(52/130;40%),其次是胃肠道(GIT) (21/130;16.2%)和中枢神经系统(13/130;10%)。在儿科病例中,头颈部(11/32;34.4%)是最常见的部位,其次是GIT (8/32;25%)。在头颈部淋巴瘤中,鼻腔和Waldeyer环是最常见的部位,其次是眼眶和口腔。胃肠道淋巴瘤的常见部位为胃、小肠和大肠。b细胞NHL占81/130 (62.3%),t细胞NHL占20/130 (15.4%),NHL(未分类)占29/130(22.3%)。在B细胞型NHL中,弥漫性大B细胞淋巴瘤(DLBCL)是最常见的亚型。结论:结外NHL的诊断是具有挑战性的,因为它与非造血肿瘤的形态学相似。免疫组化(IHC)系系测定是诊断的关键。在我们的人群中,头颈部是最常见的部位,b细胞NHL是最常见的亚型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Primary Extranodal Non-Hodgkin’s Lymphoma: An Observational Study at a Tertiary Care Teaching Centre in Northern India
Introduction: Extranodal Non-Hodgkin’s Lymphoma (NHL) constitutes approximately one fourth of all NHL. The data regarding extranodal NHL from India is however limited. Aim: To evaluate the epidemiological and histomorphological patterns of extranodal NHL in a tertiary care institute in Northern India. Materials and Methods: The retrospective observational study was conducted on data of biopsy sections retrieved from the archives for a period of four years (January 2016 to December 2019), 130 extranodal NHL cases (90 males, 40 females) that were analysed for histological features and immunohistochemical subtype. All statistical analysis was done by Statistical Package for Social Sciences (SPSS) software. The values were represented in number, percentage, mean and ratio. Results: Total of 362 cases of NHL were reported. Out of which, 130 (36%) cases were of extranodal NHL. Male to female ratio being was 2.25:1. Mean age of presentation was 38.5 years. Paediatric cases constituted (32/130; 24.6%) cases. Head and neck was the most common site (52/130; 40%) followed by Gastrointestinal Tract (GIT) (21/130; 16.2%) and central nervous system (13/130; 10%). Amongst the paediatric cases, head and neck (11/32; 34.4%) was the most common site, followed by GIT (8/32; 25%). Amongst head and neck lymphomas, nasal cavity and Waldeyer Ring were the most common sites followed by orbit and oral cavity. Common sites among the GIT lymphomas were stomach, small intestine and large intestine. The B-cell NHL constituted 81/130 (62.3%), T-cell NHL 20/130 (15.4%) and NHL (Unclassified) were 29/130 (22.3%). Amongst B-cell type NHL, Diffuse Large B Cell Lymphoma (DLBCL) was the most common subtype. Conclusion: Extranodal NHL diagnosis is challenging due to morphological similarities with non haematopoietic tumours. Lineage determination by Immunohistochemistry (IHC) serves as the key to diagnosis. In our population, head and neck was the most common site, with B-cell NHL being the most common subtype.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
71
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信