血液成分不良反应- 12年回顾性研究-迈向预防的一步

C. Vidula, Sakthisankari Shanmugasundaram, Prasanna N. Kumar
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引用次数: 0

摘要

在临床实践中,输血和血液成分是一项挽救生命的程序。然而,它与各种风险相关,从微不足道的自限性过敏反应(AR)到危及生命的过敏或溶血性输血反应。目的:分析输血相关不良事件的类型和发生率,制定预防策略。材料和方法:这是一项回顾性观察性研究,在印度泰米尔纳德邦哥印拜陀PSG医学科学与研究所病理学系进行,研究对象是2006年1月至2018年12月期间向血库报告的输血不良反应(ATR)数据。对atr进行性别、血型成分和反应性质的分析。将收集到的数据制成表格,并使用百分比进行分析。结果:研究期间共发放全血(WB)及血液成分1 60914单位。271例不良反应(女性129例,男性142例)占总发行量的0.168%,大多数是由于红细胞堆积(0.29%)。AR的发生率最高,占63.1%(女性171 75例,男性96例),其次是发热性非溶血性输血反应(FNHTR),占33.57%(男性91 42例,女性49例)。输血相关急性肺损伤(TRALI) 4例,均为男性,占总反应的1.48%;类过敏反应3例(女2例,男1例)占总反应的1.11%;溶血性输血反应2例(0.73%)。结论:本组不良反应发生率为0.168%(271 / 160.914单位),以红细胞堆积为主(0.29%)。研究期间未发生因细菌污染引起的不良反应。重要的是要确保对护理人员、实习生和住院医生进行正确的输血程序、不良反应的识别和适当的补救措施的教育。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adverse Reactions to Blood Components- A Twelve-Year Retrospective Study- A Step towards Prevention
Introduction: The transfusion of blood and blood components is a life-saving procedure in clinical practice. However, it is associated with risks that can range from trivial self-limited Allergic Reactions (AR) to life endangering anaphylactic or haemolytic transfusion reactions. Aim: To analyse the pattern and incidence of transfusion related adverse events and to develop preventive strategies. Materials and Methods: This was a retrospective, observational study conducted at Department of Pathology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India, on data of Adverse Transfusion Reactions (ATR) reported to the blood bank over a period of 12 years from January 2006 to December 2018. The ATRs were analysed with respect to gender, type of blood component, and nature of the reaction. The data collected were tabulated and the analysis was done using percentages. Results: A total of 1,60,914 units of Whole Blood (WB) and blood components were issued during the study period. A 271 adverse reactions (129 reactions in females and 142 reactions in males) were documented constituting 0.168% of the total products issued, majority were due to packed red cells (0.29%). The incidence of AR was the maximum, accounting for 63.1% of the reactions (n=171, 75 in females and 96 in males) followed by Febrile Non Haemolytic Transfusion Reactions (FNHTR) which were 33.57% (n=91, 42 in males and 49 in females). There were four cases of Transfusion Associated Acute Lung Injury (TRALI), all in males, accounting for 1.48% of the reactions, three cases of anaphylactoid reactions (2 in females and 1 in male) accounting for 1.11% of the total reactions and two cases of haemolytic transfusion reaction (0.73%). Conclusion: The frequency of adverse reactions in the present study is 0.168% (271 out of 1, 60,914 units), majority were due to packed red cells (0.29%). No adverse reactions due to bacterial contamination occurred during the study period. It is important to ensure education of nursing staff, interns, and residents regarding the correct procedure of blood transfusion, identification of adverse reactions and appropriate remedial measures for the same.
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