氧化应激在疟疾贫血中的作用:疟疾感染患者氧化应激指数的意义

Syed Ghouse Ali Hatim, D. Phaneendra, V. S. Kumar, Sasikala Thallapapaneni, Y. B. Suchetha
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引用次数: 1

摘要

简介:氧化剂和抗氧化剂水平的改变被认为与疟疾的发病机制有关。在印度南部疟疾感染和贫血患者中,氧化应激指数与氧化剂和抗氧化状态之间的关联数据有限。目的:测定疟疾患者抗氧化剂、抗氧化剂水平和氧化应激指数及其与贫血的关系。材料与方法:本病例对照研究在印度海得拉巴奥斯马尼亚总医院生物化学科进行。根据纳入标准和排除标准,共有50名年龄在20-45岁的疟疾患者被纳入病例。对照组由50名年龄和性别匹配的健康受试者组成。用紫外分光光度计标准方法测定两组患者血红蛋白(Hb)、血清丙二醛(MDA)、超氧化物歧化酶(SOD)、总抗氧化能力(TAC)。采用独立样本t检验检验各生化指标在研究组与对照组之间的差异。采用Pearson相关法研究各参数间的相关性。结果:两组患者年龄、性别匹配(p=0.39)。与对照组相比,病例中MDA显著升高(p<0.0001)。与对照组相比,SOD、血浆铁还原能力(FRAP)、Hb显著降低(p值<0.0001)。本研究发现,疟疾患者Hb与氧化应激指数(MDA/FRAP=-0.480)呈显著负相关,p值=0.0001。结论:氧化应激可能是引起疟疾贫血的原因之一。氧化剂和抗氧化剂水平的改变可能在疟疾的发病机制中起作用。与个体标记物相比,氧化应激指数被发现与疟疾贫血显著相关,表明其在这些患者中是更好的标记物。针对上述因素进行抗疟治疗可能会降低疟疾患者的发病、发病率和死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Oxidative Stress on Malarial Anaemia: Significance of Oxidative Stress Index in Patients with Malarial Infection
Introduction: An alteration of oxidant and antioxidant levels is thought to be involved in the pathogenesis of malaria. Limited data is found on association between oxidant and antioxidant status and significance of oxidative stress index in patients with malarial infection and anaemia in south Indian population. Aim: To measure the levels of oxidants and antioxidants and oxidative stress index in patients with malaria and their association with anaemia. Materials and Methods: The present case-control study was conducted in Department of Biochemistry, Osmania General Hospital, Hyderabad, India. A total of 50 subjects of malaria aged 20-45 years were included as cases based on inclusion criteria and exclusion criteria. Control group comprised of 50 healthy age and gender matched subjects. Haemoglobin (Hb), serum Malondialdehyde (MDA), Superoxide Dismutase (SOD), Total Antioxidant Capacity (TAC) was estimated in both the groups by standard methods using Ultraviolet Spectrophotometer. Independent sample t-test was used to test for the difference in all biochemical parameters among study and control groups. The study of orrelation among the parameters was done by Pearson’s correlation. Results: Both the groups were age and gender matched (p=0.39). MDA was significantly elevated in cases as compared to controls (p<0.0001). SOD, Ferric Reducing Ability of Plasma (FRAP), Hb were significantly lower in cases as compared to controls with p-value <0.0001. In the present study, it was found that there was a significant negative correlation between Hb and oxidative stress index (MDA/FRAP=-0.480) with p-value=0.0001 in patients with malaria. Conclusion: The present study concluded that oxidative stress might be a cause of malarial anaemia. Alterations in oxidant and antioxidant levels might have a role in pathogenesis of malaria. As compared to individual markers, oxidative stress index was found to be significantly associated with malarial anaemia denoting its role as a better marker in these patients. Antimalarial therapy targeting the above factors might decrease the pathogenesis, morbidity and mortality in patients with malaria.
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