凋亡蛋白抑制剂在癌症治疗研究中的临床意义

K. Tewari, S. Dhaneshwar
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引用次数: 4

摘要

细胞凋亡是一个过程,涉及一系列细胞变化,最终导致细胞死亡。这种程序性细胞死亡是生物体生长所必需的正常现象。抑制细胞凋亡可导致许多癌症、炎症和自身免疫性疾病以及病毒感染。凋亡蛋白抑制剂(IAPs)是一个结构和功能相关的蛋白家族,在细胞凋亡(程序性细胞死亡)、增殖和血管生成中起着至关重要的作用。到目前为止,已经确定了8个IAP (Survivin, XIAP, Livin, cellular IAP 1和2,ILP-2, NAIP和BRUCE/Apollon)。本文对单个蛋白的结构特征、功能和临床意义进行了详细的讨论。这些蛋白质;特别是survivin、XIAP和Livin已被发现在多种恶性肿瘤中表达,因此被各种研究小组视为感兴趣的靶标。该综述还重点介绍了针对这些iap的新治疗药物的各种1期和2期研究,这些新治疗药物正在作为单一疗法或与现有药物联合开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inhibitors of Apoptosis Proteins (IAPs): Clinical Significance in Cancer Treatment Research
Apoptosis is a process, which involves a sequence of cellular changes, which ultimately lead to cell death. This programmed cell death is a normal phenomenon required for growth of an organism. Inhibition of apoptosis can result in a number of cancers, inflammatory and autoimmune diseases and viral infections. Inhibitors of apoptosis proteins (IAPs) are a family of structurally and functionally related proteins, which play a crucial role in apoptosis (programmed cell death), proliferation and angiogenesis. Till date 8 IAPs have been identified (Survivin, XIAP, Livin, cellular IAP 1 and 2, ILP-2, NAIP and BRUCE/Apollon). The current review discusses individual protein in details with respect to its structural features, functions and clinical significance. These proteins; especially survivin, XIAP and Livin have been found to express in wide range of malignancies and hence taken as a target of interest by various research groups. The review also highlights the various Phase- 1 and 2 studies of new therapeutic agents that are being developed either as a monotherapy or in combination with existent drugs, which target these IAPs.
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