数字光处理(DLP) 3D打印技术在两层片剂制造中的应用:复合片剂的概念

Q4 Pharmacology, Toxicology and Pharmaceutics
Ivana Adamov, Đorđe Medarević, B. Ivković, A. Ivković, S. Ibrić
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引用次数: 1

摘要

自从3D打印被引入制药领域以来,它已经引起了一种范式的转变,从大规模生产到根据患者的特定需求量身定制的小批量药品。本研究旨在利用数字光处理(DLP)技术制备双层三维片剂。选择氢氯噻嗪(HHT,5%,w/w)和华法林钠(WS,5%,w/w)作为模型药物。以0.1%的光引发剂,以恒定比例的聚(乙二醇)二丙烯酸酯和聚(乙二醇)400,1:1,加入水(10%,w/w)开始印刷过程。成功打印出直径为8.00 mm、厚度为1.50 mm的单层片剂,分别含有HHT和WS,并成功打印出两种活性物质分别位于不同层的复合双层3D片剂。单层片溶出度试验显示,WS在45min后即刻释放(81.47±1.47%),HHT在8h后缓释(98.17±3.11%),两种药物的释放均明显缓慢且不完全。证实了不存在药物-聚合物相互作用和存在层状截面片剂结构。DLP技术可以简单快速地制备复合两层三维片剂,而为了实现药物完全释放,还需要进一步优化处方因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Digital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: The concept of a combined polypill
Ever since 3D printing was introduced to the field of pharmacy, it has caused a paradigm shift from the manufacturing of large-scale to small batches of medicines tailored accordingly to the specific needs of patients. This study aimed to formulate and fabricate two-layered 3D tablets using the digital light processing (DLP) technique. Hydrochlorothiazide (HHT,5%,w/w) and warfarin sodium (WS,5%,w/w) were selected as model drugs. The printing process was initiated with 0.1% of photoinitiator, at a constant ratio of poly(ethylene glycol)diacrylate and poly(ethylene glycol) 400, 1:1, with the addition of water (10%,w/w). Single-layered tablets of 8.00 mm diameter and 1.50 mm thickness, containing HHT and WS respectively, were successfully printed, as well as combined two-layered 3D tablets, with each of the active substances in separate layers. Dissolution tests of single-layered tablets showed immediate, but incomplete release of WS (81.47±1.47%, after 45min), and prolonged and complete release of HHT (98.17±3.11%, after 8h), while significantly slower and incomplete release of both drugs from the combined two-layered 3D tablets was observed. The absence of drug-polymer interaction and presence of a layered cross-sectional tablet structure were confirmed. DLP technique enables simple and rapid fabrication of combined two-layered 3D tablets, while further optimization of formulation factors is necessary to achieve complete drug release.
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来源期刊
Arhiv za Farmaciju
Arhiv za Farmaciju Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
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发文量
19
审稿时长
12 weeks
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