点击通过选择性异海松酸转化合成三唑连接的多氮杂环

IF 1 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Macroheterocycles Pub Date : 2021-01-01 DOI:10.6060/mhc200817s

M. A. Gromova, Y. Kharitonov, T. Rybalova, E. Shults

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引用次数: 1

摘要

合成了首个含有1,2,3-三唑片段和三环二萜异海松酸片段的大环海松烷型二萜。关键步骤是由16-(羧基苯基)异海松酸合成的二炔衍生物与各种双氮化脲的CuAAC反应。用单晶x射线衍射分析确定了含1,5-重氮戊烷单元的大环化合物的分子结构。

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Click Synthesis of Triazole-Linked Polyazamacrocycles through Selective Isopimaric Acid Transformations

The first macrocyclic pimarane type diterpenoids containing fragments of 1,2,3-triazole and tricyclic diterpenoid isopimaric acid moieties were synthesized. The key step was the CuAAC reaction of various diazides with the dialkyne derivative obtained from 16-(carboxyphenyl)isopimaric acid. The molecular structure of the macrocyclic compound with 1,5-diazopentane unit was determined by single crystal X-ray diffraction analysis.

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来源期刊

Macroheterocycles CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.30

自引率

21.40%

发文量

期刊介绍： The journal is a forum for the specialists investigating macroheterocyclic compounds. It publishes original experimental and theoretical works (full papers and short communications) and reviews on synthesis, structural characterization, physical and coordination chemistry as well as practical application of macroheterocycles.