HLA-G免疫检查点分子在黑色素细胞病变中的评价

Q4 Medicine

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI:10.5935/1676-2444.20200016

R. P. Gomes, Gabriela Tayrine Pereira Caetano, L. H. Sampaio, Camila R Silva, M. B. Costa, Maria Auxiliadora Cysneiro, I. Wastowski

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引用次数: 0

摘要

人白细胞抗原g (HLA-G)是主要组织相容性复合体的非经典分子。HLA-G与肿瘤发生和肿瘤逃逸过程有关。在这项研究中，我们旨在评估HLA-G在黑色素细胞病变和黑色素瘤中的表达，以确定黑色素细胞病变何时开始表达。22例皮肤活检标本行免疫组织化学;63.6%的标本中检测到HLA-G的表达。在黑色素瘤中，这种表达明显高于良性黑色素细胞病变(p < 0.002)。我们的结果表明，HLA-G的表达开始于肿瘤发生的后期。

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Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions

The human leukocyte antigen-G (HLA-G) is a non-classical molecule of the major histocompatibility complex. HLA-G has been associated with the process of tumorigenesis and tumor escape. In this study, we aim to evaluate the HLA-G expression in melanocytic lesions and in melanoma for determining when melanocytic lesions start its expression. Twenty-two skin biopsies samples were submitted to immunohistochemistry; HLA-G expression was detected in 63.6% of the samples. This expression in melanocytic cells was significantly higher in melanoma than in benign melanocytic lesions ( p < 0.002). Our results suggest that HLA-G expression starts late in the process of tumorigenesis.

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来源期刊

Jornal Brasileiro de Patologia e Medicina Laboratorial Health Professions-Medical Laboratory Technology

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Jornal Brasileiro de Patologia e Medicina Laboratorial (Brazilian Journal of Pathology and Laboratory Medicine), a continuation of Jornal Brasileiro de Patologia (Brazilian Journal of Pathology), and published quarterly (March, June, September and December) is directed towards the publication of scientific articles that contribute to the development of the area of Laboratory Medicine (Clinical Pathology, Pathology, Cytopathology). It accepts the following categories of articles: original articles, review articles, case reports, short communications, updating articles, letters to editors and reviews.