8,947例脑脊液IgG合成的定量和定性评价

Q4 Medicine
R. Domingues, G. Peres, Fernando B. Moura-Leite, C. S. Soares
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引用次数: 0

摘要

鞘内免疫球蛋白G (IgG)合成增高可在几种神经炎性疾病中发现。目的:探讨鞘内免疫产生评价的定量和定性方法。方法:回顾性分析2001 - 2017年Senne白酒Diagnóstico采集的脑脊液和血清样本数据。比较有和没有寡克隆带(ocb)的病例的细胞学、生化和免疫学数据。将有OCB (OCB+)和无OCB (OCB-)的样本进行比较,并采用ROC分析评估预测OCB存在的能力。结果:共纳入8947例样本,其中OCB+样本2599例,OCB+样本6348例。脑脊液淋巴细胞和单核细胞与OCB的存在显著相关(p < 0.001)。所有炎症参数均与OCB有显著相关性,对OCB预测能力最高的方法为IgG指数和赖伯图[受试者工作特征曲线下面积= 0.881和0.863]。小部分无OCB的病例IgG指数高(9.56%)或Reiber图显示IgG生成增加(4.6%)。结论:我们发现OCB与其他脑脊液炎症参数有很强的相关性。无OCB的脑脊液IgG合成增加的病例表明,在评估神经炎症过程时应采用定量和定性方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quantitative and qualitative evaluation of IgG synthesis in 8,947 cerebrospinal fluid samples
Introduction: Increased intrathecal immunoglobulin class G (IgG) synthesis can be found in several neuroinflammatory diseases. Objective: The aim of this study was to analyze quantitative and qualitative methods of intrathecal immunoproduction evaluation. Methods: We retrospectively assessed data from cerebrospinal fluid (CSF) and serum samples sent to Senne Liquor Diagnóstico from 2001 to 2017. Cytological, biochemical, and immunological data were compared between cases with and without oligoclonal bands (OCBs). Comparisons between samples with OCBs (OCB+) and without them (OCB-) were carried out, and the ability to predict the presence of OCBs was assessed with ROC analysis. Results: We included 8,947 samples (2,599 OCB+ samples and 6,348 OCBsamples). CSF lymphocytes and monocytes were significantly associated with the presence of OCB (p < 0.001). All the inflammatory parameters were significantly associated with OCB, and the methods with the highest predictive ability for OCB were IgG index and Reiber diagram [area under the receiver operating characteristic (AUROC) curve = 0.881 and 0.863, respectively]. A small percentage of cases without OCB had high IgG index (9.56%) or Reiber diagram, showing increased IgG production (4.6%). Conclusion: We showed a strong association between OCB and other CSF inflammatory parameters. The presence of cases with increased quantitative CSF IgG synthesis without OCB suggests that both quantitative and qualitative methods should be performed in the evaluation of neuroinflammatory processes.
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来源期刊
Jornal Brasileiro de Patologia e Medicina Laboratorial
Jornal Brasileiro de Patologia e Medicina Laboratorial Health Professions-Medical Laboratory Technology
CiteScore
1.30
自引率
0.00%
发文量
0
审稿时长
20 weeks
期刊介绍: The Jornal Brasileiro de Patologia e Medicina Laboratorial (Brazilian Journal of Pathology and Laboratory Medicine), a continuation of Jornal Brasileiro de Patologia (Brazilian Journal of Pathology), and published quarterly (March, June, September and December) is directed towards the publication of scientific articles that contribute to the development of the area of Laboratory Medicine (Clinical Pathology, Pathology, Cytopathology). It accepts the following categories of articles: original articles, review articles, case reports, short communications, updating articles, letters to editors and reviews.
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