{"title":"开发未来抗菌剂的分子靶点","authors":"M. Al-Khayyat","doi":"10.5114/BTA.2019.85325","DOIUrl":null,"url":null,"abstract":"To overcome antibiotic resistance in pathogenic microorganisms, research work is being directed towards finding alternative targets in bacteria towards which novel antibiotics can be designed. One of the targets is cell-to-cell communication pathway, also called quorum sensing which is promising since it controls the expression of virulence genes. Another possible target is the segregation apparatus that is present in low copy number plasmids that may contain antibiotic resistance genes. Cellular elements that function in division or maintain the shape of the micro-organisms may be also used as alternative targets to affect cytokinesis or cause abnormalities in shape, which can or may lead to cell lysis. Additionally, certain metabolic pathways present in microbes do not exist in mammals and, therefore, may be exploited as novel targets without affecting the human host. Screening of ligands or chemical compounds from natural products may be useful in finding inhibitors acting on the above-mentioned cellular components, and it may lead to the design of future antibiotics.","PeriodicalId":8999,"journal":{"name":"BioTechnologia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Molecular targets to develop future antimicrobials\",\"authors\":\"M. Al-Khayyat\",\"doi\":\"10.5114/BTA.2019.85325\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To overcome antibiotic resistance in pathogenic microorganisms, research work is being directed towards finding alternative targets in bacteria towards which novel antibiotics can be designed. One of the targets is cell-to-cell communication pathway, also called quorum sensing which is promising since it controls the expression of virulence genes. Another possible target is the segregation apparatus that is present in low copy number plasmids that may contain antibiotic resistance genes. Cellular elements that function in division or maintain the shape of the micro-organisms may be also used as alternative targets to affect cytokinesis or cause abnormalities in shape, which can or may lead to cell lysis. Additionally, certain metabolic pathways present in microbes do not exist in mammals and, therefore, may be exploited as novel targets without affecting the human host. Screening of ligands or chemical compounds from natural products may be useful in finding inhibitors acting on the above-mentioned cellular components, and it may lead to the design of future antibiotics.\",\"PeriodicalId\":8999,\"journal\":{\"name\":\"BioTechnologia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BioTechnologia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/BTA.2019.85325\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioTechnologia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/BTA.2019.85325","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
Molecular targets to develop future antimicrobials
To overcome antibiotic resistance in pathogenic microorganisms, research work is being directed towards finding alternative targets in bacteria towards which novel antibiotics can be designed. One of the targets is cell-to-cell communication pathway, also called quorum sensing which is promising since it controls the expression of virulence genes. Another possible target is the segregation apparatus that is present in low copy number plasmids that may contain antibiotic resistance genes. Cellular elements that function in division or maintain the shape of the micro-organisms may be also used as alternative targets to affect cytokinesis or cause abnormalities in shape, which can or may lead to cell lysis. Additionally, certain metabolic pathways present in microbes do not exist in mammals and, therefore, may be exploited as novel targets without affecting the human host. Screening of ligands or chemical compounds from natural products may be useful in finding inhibitors acting on the above-mentioned cellular components, and it may lead to the design of future antibiotics.
BioTechnologiaAgricultural and Biological Sciences-Plant Science
CiteScore
1.60
自引率
0.00%
发文量
8
审稿时长
8 weeks
期刊介绍:
BIOTECHNOLOGIA – a high standard, peer-reviewed, quarterly magazine, providing a medium for the rapid publication of research reports and review articles on novel and innovative aspects of biotechnology, computational biology and bionanotechnology.