静脉注射免疫球蛋白治疗对重症covid -19患者有作用吗?

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
Ş. Bektaş, Ç. M. Ayaz, Mehmet Eren Yuksel, S. Izdes
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引用次数: 1

摘要

“我们想评估静脉注射免疫球蛋白(IVIG)治疗重症监护病房(ICU) Covid-19患者的疗效。回顾性分析了2020年4月至2021年10月期间在安卡拉市医院三级ICU接受IVIG治疗的16例(66.7%)男性和8例(33.3%)女性成年重症Covid-19患者。患者年龄中位数为63岁(四分位间距:19)。根据IVIG治疗前后的实验室指标和临床结果对患者进行评估。经IVIG治疗的存活与死亡的Covid-19患者在年龄、性别、症状发生、合并疾病的存在、APACHE-II评分、机械呼吸机支持持续时间、ICU住院时间等方面无统计学差异。比较IVIG治疗前后的实验室值,只有丙氨酸转氨酶水平显著降低(p=0.01)。然而,5例格林-巴罗综合征患者的死亡率差异有统计学意义(p=0.001)。IVIG治疗对合并格林-巴-罗综合征的Covid-19患者有效。然而,IVIG治疗对ICU重症Covid-19患者治疗前后的实验室值、发病率和死亡率没有统计学意义上的显著影响。”
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does Intravenous Immunoglobulin Therapy Have a Role in the Treatment of Severe Coronavirus-19 Patients?
"We wanted to evaluate the efficacy of intravenous immunoglobulin (IVIG) treatment in Covid-19 patients in the intensive care unit (ICU). Sixteen (66.7%) male and 8 (33.3%) female adult severe Covid-19 patients who were treated with IVIG in the tertiary ICU between April 2020 and October 2021 at Ankara City Hospital were retrospectively reviewed. The median age of the patients was 63 (interquartile range (IQR):19). The patients were evaluated in terms of laboratory values and clinical results before and after IVIG treatment. There was no statistically significant difference between survived and deceased Covid-19 patients treated with IVIG in terms of age, gender, the onset of symptoms, presence of concomitant diseases, APACHE-II scores, duration of mechanical ventilator support, and length of stay in the ICU. When the laboratory values before and after IVIG treatment were compared, a significant decrease was identified only in alanine transaminase levels (p=0.01). However, there was a statistically significant difference in mortality in 5 patients with Guillain-Barré syndrome who all survived (p=0.001). IVIG treatment was effective in Covid-19 patients with Guillain-Barré syndrome. However, IVIG treatment did not have a statistically significant effect on pre and post-treatment laboratory values, morbidity, and mortality of severe Covid-19 patients in the ICU "
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来源期刊
Romanian Journal of Military Medicine
Romanian Journal of Military Medicine MEDICINE, GENERAL & INTERNAL-
自引率
33.30%
发文量
2
审稿时长
12 weeks
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