抗氧化剂对四氯化碳肝毒性作用的有效补救

生物物理化学(英文) Pub Date : 2014-01-15 DOI:10.4236/JBPC.2014.51001

K. Hovnanyan, V. Mamikonyan, A. Margaryan, K. Sargsyan, M. Hovnanyan, M. Karagyozyan, K. Karageuzyan

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引用次数: 7

摘要

肝脏作为中枢代谢器官，在碳水化合物、脂质和蛋白质的代谢中起着重要作用。在环境中，有许多肝毒性的外源性药物。CCl4是一种对肝细胞细胞器有毒性的自由基。研究葡萄籽提取物(GSE)、α-生育酚(α-T)对ccl4中毒大鼠肝细胞及肝组织超微结构的影响。由于细胞的生物修复作用和对腐败因素的反应，肝脏具有很高的再生能力。

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Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride

The liver, as the central metabolic organ, plays an important role in metabolism of carbohydrates, lipids and proteins. In the environment, there are many hepatotoxic xenobiotics. CCl4 is a free radical toxic for organelles of hepatocytes. The presented work was studying the character of ultrastructural changes in CCl4-intoxicated hepatocytes as well as the tissue after treatment by grape seed extract (GSE), α-tocopherol (α-T). As a result of cell bioremediation effect and reactions against corruptive factors, the liver has a high regeneration ability.

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来源期刊

生物物理化学(英文)

自引率

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发文量

144