发酵木瓜制剂阻止大鼠非酒精性脂肪性肝炎的进展

生物物理化学(英文) Pub Date : 2013-05-24 DOI:10.4236/JBPC.2013.42012

S. Murakami, F. Takayama, T. Egashira, Mitsuko Imao, A. Mori

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引用次数: 3

摘要

非酒精性脂肪性肝炎(NASH)可发展为肝硬化或肝细胞癌。氧化应激与NASH进展有关。发酵木瓜制剂(FPP)具有清除氧自由基的活性，对氧化应激相关疾病有效。我们使用大鼠NASH模型研究了FPP对NASH进展的影响。NASH大鼠血浆生化指标和肝脏脂质过氧化升高。组织学上，NASH大鼠肝脏表现为肝纤维化、线粒体功能障碍和微粒体CYP2E1过表达。髓过氧化物酶活性和核因子κ b活性也在NASH中显著升高。口服FPP可改善NASH大鼠的这些变化。这些结果表明，FPP通过其抗氧化和抗炎特性阻止NASH进展。

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Fermented papaya preparation halts the progression of non-alcoholic steatohepatitis in rats

Non-alcoholic steatohepatitis (NASH) can progress to cirrhosis or hepatocellular carcinoma. Oxidative stress is implicated in NASH progression. Fermented papaya preparation (FPP) has oxygen radical scavenging activity and is effective in oxidative stress-related diseases. We investigated the effects of FPP on NASH progression using a rat NASH model. Plasma biochemical parameters and lipid peroxidation in the liver were elevated in NASH rats. Histologically, the liver of NASH rats showed liver fibrosis, mitochondrial dysfunction and over-expression of microsomal CYP2E1. Myeloperoxidase activity and nuclear factor-kappaB activation were also markedly increased in NASH. Oral administration of FPP ameliorated these changes in NASH rats. These results suggest that FPP halts NASH progression through its anti-oxidative and antiinflammatory properties.

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来源期刊

生物物理化学(英文)

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144