尼罗河三角洲地区埃及医学生接种乙肝疫苗后的免疫反应

Reem Elmaghlob, Gamal El Didamony, Ashraf Elbahrawy, A. Abdallah, M. Hemida, A. Elwassief, M. Ali, Ahmed Alashker, A. Mohammad, M. Morsy, Hafez Abdelhafeez
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引用次数: 2

摘要

背景:在卫生保健工作者中早期推广乙型肝炎(HB)疫苗接种是控制HBV感染的重要组成部分。尚无资料评估埃及医学生接种乙肝疫苗的免疫反应。目的:本研究旨在评估医学生完成疫苗接种后的免疫反应。方法:对150名埃及医学生进行调查。所有参与研究的学生在0、1和6个月时接种了三剂重组HB疫苗。接种结束后1 ~ 2个月,采用酶免疫分析法测定乙型肝炎表面抗原(Anti-HBs)滴度、乙型肝炎表面抗原(HBsAg)和乙型肝炎核心抗原(anti-HBc)总抗体。结果:纳入的150名学生平均年龄为22.4±1.7岁(18 ~ 28岁)。男性59例(39.4%),女性91例(60.6%)。所有学生的抗hbs水平均在100 IU/L以上。纳入学生的平均抗- hbs为8994.2±6373.1 IU/L。在年龄、性别、居住地、体质指数分布等方面,抗- hbs水平无显著差异。结论:卫生保健工作者早期接种乙肝疫苗与良好的免疫应答有关,应予以鼓励。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immune Response after Hepatitis B Vaccination among Egyptian Medical Students in Nile Delta
Background: Early promotion of hepatitis B (HB) vaccination among health care workers is an important component of the HBV infection control. No available data assess immune response of HB vaccination among Egyptian medical students. Objective: we conducted this study to evaluate the immune response among medical students after completion of their vaccination schedule. Methods: A total of 150 Egyptian medical students were included. Three doses of recombinant HB vaccine had been administered to all participating students at 0, 1 and 6 months. Antibody to hepatitis B surface antigen (Anti-HBs) titers, hepatitis B surface antigen (HBsAg), and total antibody to hepatitis B core antigen (anti-HBc) were measured by enzyme immunoassay, 1 to 2 months after completion of vaccination course. Results: Among 150 students included, the mean age was 22.4 ± 1.7 years (range 18 - 28 years). Fifty nine (39.4%) were males and 91 (60.6%) were females. All students have anti-HBs levels more than 100 IU/L. The mean anti-HBs of included students was 8994.2 ± 6373.1 IU/L. There was no significant difference of anti-HBs levels regarding age, sex, residence or body mass index distribution. Conclusion: Early HB vaccination of health care workers is associated with good immune response and should be encouraged.
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