{"title":"CRISPR-Cas9系统:基因组工程和调控的强大工具","authors":"Yongmin Yan, D. Wei","doi":"10.4172/2169-0111.1000E103","DOIUrl":null,"url":null,"abstract":"In this post-genome era of advanced high-throughput DNA/RNA sequencing technologies, information may no longer be a bottleneck to understand and tackle complicated genetic diseases such as cancer. What is still lacking, however, is an efficient, reliable, and easy tool to precisely modify the cellular genome for functional genome annotation, disease modeling, and possibly even corrective gene therapy.","PeriodicalId":89733,"journal":{"name":"Advancements in genetic engineering","volume":"2 1","pages":"1-2"},"PeriodicalIF":0.0000,"publicationDate":"2013-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"The CRISPR-Cas9 System: A Powerful Tool for Genome Engineering and Regulation\",\"authors\":\"Yongmin Yan, D. Wei\",\"doi\":\"10.4172/2169-0111.1000E103\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this post-genome era of advanced high-throughput DNA/RNA sequencing technologies, information may no longer be a bottleneck to understand and tackle complicated genetic diseases such as cancer. What is still lacking, however, is an efficient, reliable, and easy tool to precisely modify the cellular genome for functional genome annotation, disease modeling, and possibly even corrective gene therapy.\",\"PeriodicalId\":89733,\"journal\":{\"name\":\"Advancements in genetic engineering\",\"volume\":\"2 1\",\"pages\":\"1-2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advancements in genetic engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2169-0111.1000E103\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advancements in genetic engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2169-0111.1000E103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The CRISPR-Cas9 System: A Powerful Tool for Genome Engineering and Regulation
In this post-genome era of advanced high-throughput DNA/RNA sequencing technologies, information may no longer be a bottleneck to understand and tackle complicated genetic diseases such as cancer. What is still lacking, however, is an efficient, reliable, and easy tool to precisely modify the cellular genome for functional genome annotation, disease modeling, and possibly even corrective gene therapy.
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