编码c-Fos、c-Jun和IER5转录因子的早期基因变异与缺血性卒中相关

K. Tadevosyan, G. Tsakanova, A. Boyajyan
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引用次数: 4

摘要

转录因子在脑卒中发生前和发生后的机制调控中起着重要作用。本研究的主要目的是评估单核苷酸多态性FOS (rs7101, rs1063169), JUN (rs11688)和IER5 (rs6425663)与亚美尼亚人群缺血性卒中的潜在关联。本研究共纳入161例缺血性脑卒中患者和165例对照组。利用序列特异性引物聚合酶链反应(PCR-SSP)对转录因子进行基因分型。使用Pearson’s Chisquare检验评估基因型、等位基因和携带频率与缺血性卒中的关系。多次检验校正p值小于0.05被认为是显著的。获得的数据显示FOS rs1063169*T、JUN rs11688* a和IER5 rs6425663*T小等位基因与缺血性脑卒中呈显著负相关。另一方面,患者组FOS基因rs7101*T小等位基因的频率分布及其携带率均显著高于对照组。我们的研究结果表明,FOS rs1063169、JUN rs11688和IER5 rs6425663 SNP的小等位基因可以被认为对缺血性卒中具有保护作用,而FOS rs7101 SNP的小等位基因则是缺血性卒中的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Variations in Immediate-early Genes Encoding c-Fos, c-Jun and IER5 Transcription Factors are Associated with Ischemic Stroke
Transcription factors make a great contribution in the regulation of mechanisms, which are involved in the preand post-stroke events. The main goal of the current study was to evaluate the potential association of single nucleotide polymorphisms FOS (rs7101, rs1063169), JUN (rs11688) and IER5 (rs6425663) with ischemic stroke in Armenian population. A total 161 patients with ischemic stroke and 165 controls were involved in this study. Transcription factors were genotyped using polymerase chain reaction with sequence-specific primers (PCR-SSP). Association of genotype, allelic and carriage frequencies with ischemic stroke was assessed using Pearson's Chisquare test. Multiple test corrected p values less than 0.05 were considered significant. The data obtained demonstrated a significant negative association between the FOS rs1063169*T, JUN rs11688*A and IER5 rs6425663*T minor alleles with ischemic stroke. On the other hand, the frequency distribution of rs7101*T minor allele of FOS gene and its carriage rate in the group of patients were significantly higher than in controls. Our results indicate that the minor alleles of FOS rs1063169, JUN rs11688 and IER5 rs6425663 SNPs can be considered as protective against ischemic stroke, whereas the minor allele of FOS rs7101 SNP represents a risk factor for this disease.
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