血管肌成纤维细胞瘤:一罕见良性间充质肿瘤的影像学及病理分析

A. Kulkarni, M. Tinmaswala, S. Shetkar, S. Kondekar
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引用次数: 2

摘要

血管肌纤维母细胞瘤、侵袭性血管粘液瘤和细胞血管纤维瘤是罕见的间质肿瘤,具有许多重叠的放射学、组织病理学和免疫组织化学特征。在这些肿瘤中,血管肌成纤维细胞瘤是相对良性的间充质肿瘤,复发率极低。由于其清晰的边界和光滑的外观,临床上常与bartholin腺囊肿混淆。由于组织病理特征重叠,即使是经验丰富的病理学家也很难区分这些间充质肿瘤。早期的促球蛋白反应性被认为是血管肌成纤维细胞瘤所特有的,但最近许多侵袭性血管粘液瘤也发现促球蛋白阳性。超声,计算机断层扫描和磁共振成像可能有助于诊断和排除更险恶的恶性肿瘤。血管肌成纤维细胞瘤通常表现为界限清晰的病变,其组织病理学特征是伴有丰富的血管和染色质分散的间质细胞的低细胞和高细胞交替的水肿区。免疫组织化学可以进一步帮助诊断。我们在此报告一例阴道血管肌成纤维细胞瘤。诊断依据影像学,经组织病理学和免疫组织化学证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Angiomyofibroblastoma: Imaging and histopathology of a rare benign mesenchymal tumor
Angiomyofibroblastomas, aggressive angiomyxomas and cellular angiofibromas are rare mesenchymal tumours with many overlapping radiological, histopathological and immunohistochemical features. Amongst these tumours angiomyofibroblastoma is relatively benign mesenchymal tumour with very low chances of recurrence. It is clinically confused with bartholin gland cyst due to its well demarcated and smooth appearance. Due to overlapping histopathological features its very difficult even for experienced pathologists to differentiate between these mesenchymal tumours. Earlier desmin reactivity was thought to be specific for angiomyofibroblastoma but recently many aggressive angiomyxomas have also been found to be positive for desmin. Ultrasound, computed tomography and magnetic resonance imaging may be useful in diagnosis and ruling out more sinister malignancies. A well demarcated lesion with characteristic histopathological appearance of alternating hypo and hypercellular edematous regions with abundant blood vessels and stromal cells with dispersed chromatin is usually seen in angiomyofibroblastoma. Immunohistochemistry may further help in diagnosis. We here report a case of vaginal angiomyofibroblastoma. The diagnosis was made on the basis of imaging and was confirmed by histopathology and immunohistochemistry.
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