是否应广泛应用PRIMA预后指数代替FLIPI2评价滤泡性淋巴瘤的预后?

IF 0.1
Ngoc Dung Nguyen, Hai Pham, Thi Nguyet Anh Phi, Thi Lan Huong Nguyen, M. Vu
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引用次数: 0

摘要

最近的研究表明,PRIMA-PI(预后指数)是预测滤泡性淋巴瘤(FL)患者的一种简单工具。为了对滤泡性淋巴瘤的预后提供一些经验,我们进行了一项研究,分析了PRIMA-PI与FLIPI2(滤泡性淋巴瘤国际预后指数)在滤泡性淋巴瘤预后中的价值。回顾性分析了45例新诊断为滤泡性淋巴瘤并接受化疗的患者。所有患者均行骨髓活检以检测骨髓受累情况。在组织学基础上,根据WHO定义分级。OS (overall survival)分析采用Kapplan-Meyer方法和Cox比例风险模型,评估预后指标FLIPI2、PRIMA-PI和FL的组织学分级(grade)。根据FLIPI2,低危组、中危组和高危组的9年OS率分别为100%、52.9%和49.5%;分别。根据PRIMA-PI,低危组、中危组和高危组的9年OS率分别为83.9%、68.2%和43.3%;分别。按年级分,1、2、3a、3b年级的9年生存率分别为83.3%、73%、59.3%、25%;分别。单因素和多因素分析显示,只有FLIPI2和分级是真正独立的OS预后因素(P =0.03和0.012);分别。相反,我们尚未发现PRIMA-PI在OS预后中的意义,(P =0.056)。当计划广泛应用PRIMA-PI代替FLIPI2用于滤泡性淋巴瘤的预后时,应谨慎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Should PRIMA Prognostic Index Be Widely Applied Instead of FLIPI2 in the Prognosis of Follicular Lymphoma?
Recent studies have suggested that PRIMA-PI (Prognostic Index) is a simple tool for predicting patients with follicular lymphoma (FL). With the desire to contribute some experience in the prognosis of FL, we conducted a study to analyze the value of PRIMA-PI versus FLIPI2 (Follicular Lymphoma International Prognostic Index) in the prognosis of FL. Forty-five patients diagnosed with newly follicular lymphoma who received chemotherapy were retrospectively analyzed. All patients underwent bone marrow biopsy to detect bone marrow involvement. Based on histology, the grade was defined according to WHO. The Kapplan-Meyer method and the Cox proportion hazards model were used in the OS (overall survival) analysis to evaluate prognostic indices such as FLIPI2, PRIMA-PI, and the histological classification of FL (grade). According to FLIPI2, the 9-year OS rate of the low-risk group, the intermediate-risk group, and the high-risk group was 100%, 52.9%, and 49.5%; respectively. According to PRIMA-PI, the OS rate for the low-risk group, the intermediate-risk group, and the high-risk group at 9 years was 83.9%, 68.2%, and 43.3%; respectively. According to grade, the 9-year OS rate for grades 1, 2, 3a, and 3b was 83.3%, 73%, 59.3%, and 25%; respectively. Univariate and multivariate analysis showed that only FLIPI2 and grade were truly independent prognostic factors for OS with P =0.03, and 0.012; respectively. On the contrary, we had not yet found the significance of PRIMA-PI in the prognosis of OS, ( P =0.056). Caution should be exercised when planning to apply PRIMA-PI widely instead of FLIPI2 in the prognosis of follicular lymphoma.
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