{"title":"乳房平滑肌瘤型肌纤维母细胞瘤伴异型增生","authors":"M. Zamecnik, Karol Macuch","doi":"10.5455/JIHP.20170326021845","DOIUrl":null,"url":null,"abstract":"An unusual case of leiomyomatous-type mammary myofibroblastoma (MFB) with symplastic nuclear atypia is described in this report. The tumor occurred in a 67-year-old woman as a palpable 1 cm nodule. Histologically, the lesion was composed of myoid-appearing spindle cell fascicles with immunohistochemical positivity for CD34, Bcl-2, smooth muscle actin, desmin, h-caldesmon, calponin, estrogen receptor, p16, and cyclin-D1. Many tumor cells exhibited nuclear atypia resembling closely that of atypical (bizarre, symplastic) leiomyoma of the uterus. Mitotic activity was very low and MIB-1 index was 3%. Leiomyomatous MFB with atypia mimics malignant lesions which has to be considered in differential diagnosis.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"1 1","pages":"1"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia\",\"authors\":\"M. Zamecnik, Karol Macuch\",\"doi\":\"10.5455/JIHP.20170326021845\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An unusual case of leiomyomatous-type mammary myofibroblastoma (MFB) with symplastic nuclear atypia is described in this report. The tumor occurred in a 67-year-old woman as a palpable 1 cm nodule. Histologically, the lesion was composed of myoid-appearing spindle cell fascicles with immunohistochemical positivity for CD34, Bcl-2, smooth muscle actin, desmin, h-caldesmon, calponin, estrogen receptor, p16, and cyclin-D1. Many tumor cells exhibited nuclear atypia resembling closely that of atypical (bizarre, symplastic) leiomyoma of the uterus. Mitotic activity was very low and MIB-1 index was 3%. Leiomyomatous MFB with atypia mimics malignant lesions which has to be considered in differential diagnosis.\",\"PeriodicalId\":91320,\"journal\":{\"name\":\"Journal of interdisciplinary histopathology\",\"volume\":\"1 1\",\"pages\":\"1\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of interdisciplinary histopathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5455/JIHP.20170326021845\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of interdisciplinary histopathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/JIHP.20170326021845","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia
An unusual case of leiomyomatous-type mammary myofibroblastoma (MFB) with symplastic nuclear atypia is described in this report. The tumor occurred in a 67-year-old woman as a palpable 1 cm nodule. Histologically, the lesion was composed of myoid-appearing spindle cell fascicles with immunohistochemical positivity for CD34, Bcl-2, smooth muscle actin, desmin, h-caldesmon, calponin, estrogen receptor, p16, and cyclin-D1. Many tumor cells exhibited nuclear atypia resembling closely that of atypical (bizarre, symplastic) leiomyoma of the uterus. Mitotic activity was very low and MIB-1 index was 3%. Leiomyomatous MFB with atypia mimics malignant lesions which has to be considered in differential diagnosis.
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