6周与12周抗生素治疗非手术糖尿病足骨髓炎的疗效比较

Manouchehr Iranparvar, M. Arzanlou, Elnaz Afrouzeh
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引用次数: 3

摘要

背景:关于糖尿病足骨髓炎(DFO)的最佳抗生素治疗时间的证据很少。因此,对于非手术治疗的糖尿病患者并发足部创伤的骨髓炎,抗生素治疗的最佳时间目前尚不清楚,需要进一步的研究。本研究旨在比较非手术治疗DFO的6周和12周抗生素治疗。方法:这是一项介入性研究,对30例无手术指征的DFO患者进行了研究,随机分为两组(6周和12周抗生素治疗)。c反应蛋白(CRP)、白蛋白、红细胞沉降率(ESR)、糖化血红蛋白(HbA1c)、肌酐、基线时空腹血糖(FBS)、两小时后空腹血糖(FBS)、白细胞(WBC)、中性粒细胞绝对计数及临床结果(完全愈合和不愈合百分比、完全愈合时间、测量两组患者的放射学异常及治疗后疾病复发率),用SPSS 21软件进行统计学分析。结果:研究期间,6周治疗组CRP (p=0.03)、ESR (p=0.03)、2小时血糖(p=0.02)、WBC (p=0.04)、绝对中性粒细胞计数(p=0.04)和12周治疗组CRP (p=0.02)、ESR (p=0.02)、HbA1c (p=0.04)、基线FBS (p=0.04)、2小时后FBS (p=0.01)、WBC (p=0.02)、绝对中性粒细胞计数(p=0.04)的变化均有统计学意义。两组患者的临床结果无显著差异。结论:非手术治疗DFO 6周与12周抗生素治疗效果相同。因此,在这些患者中,6周的DFO抗生素治疗就足够了。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the efficacy of six-week versus twelve-week antibiotic therapy for the treatment of nonsurgical diabetic foot osteomyelitis
Background: There is little evidence regarding the optimal duration of antibiotic therapy for diabetic foot osteomyelitis (DFO). So, the optimal duration of antibiotic treatment of osteomyelitis complicating foot wounds in non–surgically treated diabetic patients is currently unknown and needs more studies in the future. This study aimed to compare six-week versus twelve-week antibiotic therapy for the treatment of nonsurgical DFO. Methods: This was an interventional study that was performed on 30 patients with DFO without surgical indications who were randomly divided into two groups (six-week versus twelve-week antibiotic therapy). Changes of parameters such as C-reactive protein (CRP), albumin, erythrocyte sedimentation rate (ESR), HbA1c, creatinine, fasting blood sugar (FBS) at baseline, FBS after two hours, white blood cell (WBC), absolute count of neutrophil and clinical outcomes (percentage of complete healing and non-healing, the time of complete healing, radiological abnormality and recurrence of the disease after treatment) were measured in the two groups and then analyzed by statistical methods in SPSS version 21. Results: During the study period, values of CRP (p=0.03), ESR (p=0.03), two-hour glucose (p=0.02), WBC (p=0.04) and absolute neutrophil count (p=0.04) in the six-week treatment group and the values of CRP (p=0.02), ESR (p=0.02), HbA1c (p=0.04), FBS at baseline (p=0.04), FBS after two-hour (p=0.01), WBC (p=0.02) and absolute neutrophil count (p=0.04) in the twelve-week treatment group changed significantly. There was no significant difference concerning the clinical outcomes between the two groups. Conclusions: The results showed that six and twelve-week antibiotic therapy had the same efficacy in the treatment of non-surgically DFO. Therefore, six-week antibiotic therapy of DFO could be sufficient in these patients.
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