腰椎间盘突出症患者体内 Paraoxonase 1 的活性和表型分布。

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY

Turkish neurosurgery Pub Date : 2024-01-01 DOI:10.5137/1019-5149.JTN.44307-23.2

Utku Adilay, Nahit Gencer, Kubra Cikrikci, Muhammed Fatih Sari, Emad Adden Abdallah, Bulent Guclu

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引用次数: 0

摘要

目的：腰椎间盘突出症（LDH）影响着许多人，氧化应激与椎间盘退化有关，因此也与 LDH 有关。副氧合酶 1（PON1）具有抗氧化特性，其活性会因基因变异和种族背景而有所不同。本研究旨在比较 LDH 患者和健康人的 PON1 活性和表型分布：研究对象包括 40 名 LDH 患者和 42 名健康人。采用分光光度法测定血清中 PON1 和芳香族酯酶的活性。PON1 比率代表盐刺激的副氧合酶/芳香族酯酶水平，该比率呈三态分布。该比率用于确定每个受试者的不同表型：QQ、QR 和 RR：结果：LDH 患者的 PON1 活性低于健康人（P 0.05）。与健康组相比，LDH 患者的 QQ 表型具有统计学意义（P 0.05）：我们发现 LDH 患者的 PON1 活性较低，这表明低 PON1 活性和 PON1 QQ 表型可能是导致 LDH 发生的危险因素。

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Paraoxonase 1 Activity and Phenotype Distribution in Lumbar Disc Herniation Patients.

Aim: To compare the Paraoxonase 1 (PON1) activity and phenotype distribution between lumbar disc herniation (LDH) patients and healthy individuals.

Material and methods: This research included 40 LDH patients and 42 healthy individuals. Spectrophotometric assays were performed to determine the serum PON1 and arylesterase activities. The PON1 ratio, which represents the salt-stimulated PON/ arylesterase level, demonstrated a trimodal distribution. This ratio was applied to identify the different phenotypes; QQ, QR, and RR of each subject.

Results: The LDH patients had lower PON1 activity than the healthy individuals (p < 0.05). LDH patients had a statistically significant QQ phenotype compared to the healthy subjects (p < 0.05).

Conclusion: LDH patients had statistically lower PON1 activity, suggesting that the low PON1 activity and PON1 QQ phenotype may be a risk factor for LDH occurrence.

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来源期刊

Turkish neurosurgery 医学-临床神经学

CiteScore

1.50

自引率

12.50%

发文量

126

审稿时长

2 months

期刊介绍： Turkish Neurosurgery is a peer-reviewed, multidisciplinary, open access and totally free journal directed at an audience of neurosurgery physicians and scientists. The official language of the journal is English. The journal publishes original articles in the form of clinical and basic research. Turkish Neurosurgery will only publish studies that have institutional review board (IRB) approval and have strictly observed an acceptable follow-up period. With the exception of reference presentation, Turkish Neurosurgery requires that all manuscripts be prepared in accordance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals.