B. Ernazarova, Taitokur Zhusubaliev, Zarylkan Asilbek kyzy, Aida Bakirova, G. Zhusupbaeva, Orozby Akparalieva, Z. Abdullaeva, Nasibakhon Razykova, Asilkan Dzhumanazarova, G. Apryshko, Alina Orozmatova
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引用次数: 1
摘要
对N-(β- d -半乳糖酰基)-硫代氨基脲类化合物进行计算机分析，结果表明该化合物具有抗菌(抗细菌)、抗结核(抗结核)、抗病毒(抗流感)、抗肿瘤(抗肿瘤)9 > Pa > 0.5的高概率，具有细胞毒性/细胞毒性(细胞抑制剂/细胞毒性)活性的低概率。体外和体内实验研究表明，所研究的新合成化合物N-(β- d -半乳糖酰基)-硫代氨基脲在所研究浓度下具有明显的杀菌和抑菌作用。
Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods
Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.
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