三支冠状动脉旁路移植术治疗14岁家族性高胆固醇血症患儿一例

S. Shirish, S. Kamath, Sagar C.V. Sunil, Bedjirgi Chidanand, K. Nitin
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引用次数: 1

摘要

家族性高胆固醇血症是一种由低密度脂蛋白(LDL)受体基因突变引起的遗传性疾病。这种疾病的纯合子型是罕见的,在生命的早期引起肌腱黄瘤和冠状动脉疾病。家族性纯合子型高胆固醇血症引起的过早冠状动脉闭塞病可能需要在儿童和年轻人中进行冠状动脉搭桥手术。行双侧带蒂乳腺内动脉及隐静脉三支冠状动脉旁路移植术,无不良反应。患有家族性高胆固醇血症的儿童患者可能会出现过早的冠状动脉粥样硬化,需要冠状动脉旁路移植术。原位乳内动脉移植是首选。据我们所知,他是英语文献中报道的接受冠状动脉搭桥手术的最年轻的患者之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Triple Vessel Coronary Artery Bypass Grafting in a 14-year-old Child with Familial Hypercholesterolemia-A Rare Case Report
Familial hypercholesterolemia is a genetic disorder caused by a mutation in the low density lipoprotein (LDL) receptor gene. The homozygous type of the disease is rare and causes tendon xanthomas and coronary artery disease during the early years of life. Premature coronary artery occlusive disease in familial homozygous hypercholesterolemia might necessitate coronary bypass surgery in children and young adults We present the case of a 14-year-old boy with familial hypercholesterolemia and coronary artery disease. He underwent triple-vessel coronary artery bypass grafting with bilateral pedicled internal mammary artery and saphenous vein grafting without adverse events. Pediatric patients with familial hypercholesterolemia may present with premature coronary atherosclerosis requiring coronary artery bypass grafting. In situ internal mammary artery grafts should be the graft of choice. To the best of our knowledge, he is one of the youngest such patients reported in the English-language literature who underwent coronary artery bypass surgery.
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