Clinical Efficacy of Bioactive Glass in Combination with Platelet Rich Fibrin in Management of Gingival Recession Defects: A Prospective Comparative Study

Background: Various biomaterials have been employed along with Coronally advanced flap (CAF) in root coverage procedures. The combined efficacy of bioactive glass and Platelet rich fibrin in management of gingival recession needs to be evaluated. Aim: The aim of the present study was to clinically evaluate the efficacy of bioactive glass putty, platelet rich fibrin (PRF) and a combination of both in management of maxillary gingival recession defects. Materials and methods: 31 patients with 60 Millers class I/II recession defects were treated with one of the following interventions; GROUP I: CAF alone, GROUP II, III and IV: CAF+Bioactive glass, CAF+PRF,CAF+ Bioactive glass+PRF respectively Clinical parameters such as recession height (RH), recession width (RW), probing pocket depth (PPD), clinical attachment level (CAL), width of attached gingiva (WAG),keratinized tissue height (KTH) were evaluated at baseline for 6 months. Mean root coverage (RC%), changes in biotype, RES and VAS aesthetic scores evaluated at the end of 6 months intervals. Results: RH and RW showed statistically significant reduction from baseline to 6 months in all the groups (p ≤ 0.05). At the end of 6 months, the mean RC% was 61.0% ± 34.3%, 75.5% ± 25.9%, 67.2% ± 32.8% and 81.7% ± 28.6% in Group I, II, III and IV respectively. Intergroup analysis showed no statistically significant difference of parameters between groups at any time point. Conclusion: All the therapeutic interventions were effective in management of gingival recession defects. Though, group IV showed greater mRC% when compared to other groups, intergroup analysis failed to show any statistical significance.