{"title":"丙型肝炎病毒感染:综述","authors":"J. F. Botha","doi":"10.4314/SAGR.V1I2.30700","DOIUrl":null,"url":null,"abstract":"Extracted from text ... REVIEW \nThe South African Gastroenterology Review - November 2003 4 \nHepatitis C virus infection \nsubtypes with sequence homology of 77 - 80 %.5 Certain \ngenotypes predominate in certain geographic areas \nand genotype 5 is found almost exclusively in South \nAfrica. Genotype predicts responsiveness to antiviral \ntherapy6 and it is more difficult to achieve a sustained \nviral response in patients with genotype 1 than in those \nwith genotypes 2 and 3. Preliminary data suggest that \ngenotype 5 is also less responsive to anti-viral therapy. \nQuasispecies are closely related yet heterogenous sequences \nof the HCV genome within an infected individual. \n7 ..","PeriodicalId":39144,"journal":{"name":"South African Gastroenterology Review","volume":"1 1","pages":"4-7"},"PeriodicalIF":0.0000,"publicationDate":"2004-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Hepatitis C virus infection: review\",\"authors\":\"J. F. Botha\",\"doi\":\"10.4314/SAGR.V1I2.30700\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Extracted from text ... REVIEW \\nThe South African Gastroenterology Review - November 2003 4 \\nHepatitis C virus infection \\nsubtypes with sequence homology of 77 - 80 %.5 Certain \\ngenotypes predominate in certain geographic areas \\nand genotype 5 is found almost exclusively in South \\nAfrica. Genotype predicts responsiveness to antiviral \\ntherapy6 and it is more difficult to achieve a sustained \\nviral response in patients with genotype 1 than in those \\nwith genotypes 2 and 3. Preliminary data suggest that \\ngenotype 5 is also less responsive to anti-viral therapy. \\nQuasispecies are closely related yet heterogenous sequences \\nof the HCV genome within an infected individual. \\n7 ..\",\"PeriodicalId\":39144,\"journal\":{\"name\":\"South African Gastroenterology Review\",\"volume\":\"1 1\",\"pages\":\"4-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-08-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"South African Gastroenterology Review\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/SAGR.V1I2.30700\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"South African Gastroenterology Review","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/SAGR.V1I2.30700","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Extracted from text ... REVIEW
The South African Gastroenterology Review - November 2003 4
Hepatitis C virus infection
subtypes with sequence homology of 77 - 80 %.5 Certain
genotypes predominate in certain geographic areas
and genotype 5 is found almost exclusively in South
Africa. Genotype predicts responsiveness to antiviral
therapy6 and it is more difficult to achieve a sustained
viral response in patients with genotype 1 than in those
with genotypes 2 and 3. Preliminary data suggest that
genotype 5 is also less responsive to anti-viral therapy.
Quasispecies are closely related yet heterogenous sequences
of the HCV genome within an infected individual.
7 ..
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