孕激素过早升高的发生率及其对体外受精周期的影响

O. Abiodun, A.O. Omobuwa, A. Fakunle, V.T. Oluwagbaye, M. Komolafe, O. Adewale, A. Akindele, A. Fasanu, J. Komolafe
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引用次数: 0

摘要

背景:与自然周期相比,卵泡晚期使用促性腺激素刺激卵巢与早孕激素升高(PPR)有关。关于卵泡晚期PPR的影响存在两种观点,一种观点认为PPR发生时对体外受精(IVF)的结果有不利影响,而另一种观点认为PPR对IVF结果没有不利影响。该研究旨在确定被评估队列数据中小反刍兽疫的发生率;孕酮截断水平两侧的妊娠率以及PPR与妊娠率之间的关系。方法:对114例患者和捐卵者的资料进行描述性回顾性队列研究。使用IBM SPSS Statistics 25对连续和分类数据进行分析。结果:IVF周期HCG日平均血清黄体酮为2.490±1.355,PPR发生率为55%。滤泡数大于13的受试者发生PPR的几率是滤泡数≤13的受试者的6.7倍。受试者的卵泡数量和年龄与黄体酮水平密切相关。与hcg前P4 < 1.5ng/ml的受试者相比,PPR受试者怀孕的几率低1.5倍。结论:体外受精周期hcg前孕酮水平与妊娠结局呈正相关
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Premature progesterone rise incidence & its effects on in vitro fertilization cycles
Background: Ovarian stimulation using gonadotropins is associated with premature progesterone rise (PPR) in late follicular phase compared to natural  cycle. Two schools of thoughts exist concerning implications of PPR during late follicular phase with one insisting that outcome of in vitro fertilization  (IVF) is adversely affected when PPR occurs while the second school of thought argues that PPR has no adverse effect on IVF outcome. The study is aimed  at determining the incidence of PPR in the cohort data evaluated; pregnancy rates across the sides of adopted cut-off level of progesterone and  association if any between PPR & pregnancy rates. Methods: It was a descriptive retrospective cohort study of data of 114 patients and egg donors.. Analysis of continuous & categorical data was done  using IBM SPSS Statistics 25. Results: Mean serum progesterone on HCG day of IVF cycle among the cohort was 2.490±1.355 with a PPR incidence of 55%.  The odds of having PPR was 6.7 times higher among subjects with follicular number more than 13 compared to subjects with follicular numbers ≤13 .  Number of follicles retrieved & age of subjects were strongly associated with progesterone level. The odds of subject with PPR getting pregnant was  found to be 1.5 times less compared to the subjects with pre-HCG P4 < 1.5ng/ml. Conclusion: Pre-HCG progesterone level is positively associated with  pregnancy outcome in IVF cycles 
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