从四翅目四胸膜果实中分离的苷类植物芳旦苷的神经药理学评价

Discovery and Innovation Pub Date : 2009-02-16 DOI:10.4314/DAI.V19I3.15799

.. A.O.Aderibigbe, E. Iwalewa, .. S.K.Adesina, .. O.E.Ukponmwan, .. A.O.Adebanjo

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引用次数: 4

摘要

研究了从四翅果中分离的n -乙酰化苷Aridanin Ð对小鼠运动、探索、刻板行为和六巴比妥酮诱导睡眠时间(HIST)的神经药理作用。Aridanin(15和30 mg/kg i.p)对新奇诱导的饲养、梳理、身体抓伤和探索行为产生剂量依赖性抑制。它还增强了六巴比妥诱导的睡眠时间(HIST)，但没有改变阿吗啡诱导的刻板行为。这些作用提示其具有较强的中枢抑制作用，可能在本质上具有镇静作用，但缺乏精神药理学活性。关键词:紫檀苷;中央活动，镇静，四翅果发现与创新Vol. 19 (3) 2007: pp. 177-181

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Neuropharmacological Evaluation of Aridanin, a Glycoside Isolated from Tetrapleura tetraptera Fruit

The neuropharmacological effects of Aridanin Ð an N-acetylated glycoside isolated from Tetrapleura tetraptera fruit was examined for locomotory, exploratory, stereotyped behaviours and hexobarbitone-induced sleeping time (HIST) in mice. Aridanin (15- and 30 mg/kg i.p) produced a dose-dependent inhibition of novelty-induced rearing, grooming, body scratching and exploratory behaviour. It also potentiated the hexobarbitone-induced sleeping time (HIST), but did not change the stereotyped behaviour induced by apomorphine. These effects of aridanin suggest that it has a strong central depressant action which may be sedative in nature but lack psychopharmacological activities Keywords : Aridanin; central activities, sedation, Tetrapleura tetraptera fruit Discovery and Innovation Vol. 19 (3) 2007: pp. 177-181

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Discovery and Innovation

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