N. Watanabe, K. Kawase, Chisato Tawada, K. Yoneda, K. Hirai, Ayumi Niwa, Takuji Tanaka
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A Case Report of Multiple Cylindroma with Immunohistochemical Features
Cylindroma is a benign skin appendageal
tumor arising from pluripotent stem cells in the follicle. Multiple cylindroma
typically occurs as a component of Brooke-Spiegler syndrome or as the only skin
lesion of familial cylindromatosis. We herein report an unusual case of
multiple cylindroma involving the trunk without any other features of
Brooke-Spiegler syndrome and no family history supporting the possibility of
familial cylindromatosis. Immunohistochemical features of CYLD and NF-κB, which
are involved in the pathogenesis of cylindroma, in the tumors are also
presented.