MLL-r白血病

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-07-20 DOI:10.4172/2329-6917.1000E116

R. Marschalek

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引用次数: 3

摘要

25年前，在染色体11q23上发现了HTRX, HRX, ALL-1, MLL基因，现在更名为KMT2A，并显示由于染色体易位平衡，由两个不同的基因AF4和ENL重排。在Carlo Croce和Michael clear的实验室中发现的这两个染色体易位，是一个与急性白血病相关的新研究领域的起点[1,2]。

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MLL-r Leukemia

25 years ago the HTRX, HRX, ALL-1, MLL gene, now renamed to KMT2A, has been discovered at chromosome 11q23 and shown to be rearranged with two different genes, AF4 and ENL, due to balanced chromosomal translocations. These two chromosomal translocations discovered in the labs of Carlo Croce and Michael Cleary-were the starting point for a new field of research associated with acute leukemia [1,2].

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Journal of leukemia (Los Angeles, Calif.)

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