慢性淋巴细胞白血病伴CD8表达异常及非典型形态1例报告及复习

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2017-01-01 DOI:10.4172/2329-6917.1000242

Bowen Li, D. Amato, Chen Wang

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引用次数: 0

摘要

慢性淋巴细胞白血病(CLL)是一种成熟的b细胞肿瘤，具有独特的免疫表型。本文报告一例罕见的伴有t细胞标志物CD8共表达的CLL。分子分析证实免疫球蛋白基因克隆，t细胞受体β和γ基因无克隆重排。细胞形态不典型CLL，具有类似反应性T淋巴细胞的特征。表型和形态学的发现可能代表一个CLL变异。

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Chronic Lymphocytic Leukemia with Aberrant CD8 Expression and Atypical Morphology: A Case Report and Review

Chronic lymphocytic leukemia (CLL) is a mature B-cell neoplasm with characteristic immunophenotype. This report presents a rare case of CLL with co-expression of T-cell marker CD8. The molecular analysis confirmed clonal immunoglobulin genes and no clonal rearrangement for T-cell receptor β and γ genes. The cell morphology was atypical of CLL, with features resembling reactive T lymphocytes. The phenotypic and morphologic findings may represent a CLL variant.

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Journal of leukemia (Los Angeles, Calif.)

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